Recurrent acute anterior uveitis is a frequent extra-articular manifestation of the axial
spondyloarthropathies (AxSpA); chronic inflammatory diseases affecting the spine, enthesis …

Purpose: Anterior uveitis is the most common anatomic subset of uveitis. We developed a
novel multi-parametric flow cytometry panel to identify immune dysregulation signatures in …

Introduction Uveitis, or intraocular inflammatory disease, is a frequent extra-articular
manifestation of several forms of arthritis. Despite the frequent co-occurrence of uveitis and …

T-helper type 17 cells (TH17) are implicated in rodent models of immune-mediated
diseases. Here we report their involvement in human uveitis and scleritis, and validate our …

Choroidal neovascularization (CNV) is a characteristic of age-related macular degeneration.
Genome-wide association studies have provided evidence that the immune system is …

Experimental autoimmune uveitis (EAU) represents autoimmune uveitis in humans. Here we
examined the role of the IL-23/IL-17 pathway in EAU. We immunized IL-23p19, IL-12p35, IL …

IL-21 is a pleiotropic type 1 cytokine that shares the common cytokine receptor γ-chain, γc,
with IL-2, IL-4, IL-7, IL-9, and IL-15. IL-21 is most homologous to IL-2. These cytokines are …

Purpose: The purpose of this study was to elucidate the effects of interleukin (IL)-38 on
experimental autoimmune uveitis (EAU) and its underlying mechanisms. Methods: Mice with …

Purpose:: Previous studies have shown that while IL-17+ IRBP-specific T cells have a strong
pathogenic effect in EAU, the major cytokine produced by these cells-IL-17 does not always …

The signature cytokine of Th17 cells, IL-17A, is a pro-inflammatory cytokine associated with
various autoimmune diseases in patients and in animal models. However, clinical trials …