Tissues comprise a multiplicity of specialized cell types that must coordinate state changes
in order to function collectively. These state changes are orchestrated by coordinated direct …

Cell dynamics and biological function are governed by intricate networks of molecular
interactions. Inferring these interactions from data is a notoriously difficult inverse problem …

Rapid advances in high-throughput technologies have produced distinct biomedical data
sets that can be analyzed using mathematical and statistical models including network …

Cells, as complex systems, consist of diverse interacting biomolecules arranged in dynamic
hierarchical modules. Recent advances in deep learning methods now allow one to encode …

A key challenge in precision medicine lies in understanding molecular-level underpinnings
of complex human disease. Biological networks in multicellular organisms can generate …

Cells function and respond to changes in their environment by the coordinated activity of
their molecular components, including mRNAs, proteins and metabolites. At the heart of …

Network biology, an interdisciplinary field at the intersection of computational and biological
sciences, is critical for deepening understanding of cellular functioning and disease. While …

Cells are the basic building blocks of life, and understanding how they transition from one
state to another is a fundamental question in cell biology. Advances in single-cell genomics …

Cellular signaling systems play a vital role in maintaining homeostasis when a cell is
exposed to different perturbations. Components of the systems are organized as hierarchical …

Much of contemporary systems biology owes its success to the abstraction of a network, the
idea that diverse kinds of molecular, cellular, and organismal species and interactions can …