Exercise is associated with younger methylome and transcriptome profiles in human skeletal muscle
Exercise training prevents age‐related decline in muscle function. Targeting epigenetic
aging is a promising actionable mechanism and late‐life exercise mitigates epigenetic aging …
aging is a promising actionable mechanism and late‐life exercise mitigates epigenetic aging …
Late‐life exercise mitigates skeletal muscle epigenetic aging
There are functional benefits to exercise in muscle, even when performed late in life, but the
contributions of epigenetic factors to late‐life exercise adaptation are poorly defined. Using …
contributions of epigenetic factors to late‐life exercise adaptation are poorly defined. Using …
Recurrent training rejuvenates and enhances transcriptome and methylome responses in young and older human muscle
S Blocquiaux, M Ramaekers… - JCSM Rapid …, 2022 - Wiley Online Library
Background The interaction between the muscle methylome and transcriptome is
understudied during ageing and periods of resistance training in young, but especially older …
understudied during ageing and periods of resistance training in young, but especially older …
Comparative transcriptome and methylome analysis in human skeletal muscle anabolism, hypertrophy and epigenetic memory
Transcriptome wide changes in human skeletal muscle after acute (anabolic) and chronic
resistance exercise (RE) induced hypertrophy have been extensively determined in the …
resistance exercise (RE) induced hypertrophy have been extensively determined in the …
Meta‐analysis of genome‐wide DNA methylation and integrative omics of age in human skeletal muscle
Background Knowledge of age‐related DNA methylation changes in skeletal muscle is
limited, yet this tissue is severely affected by ageing in humans. Methods We conducted a …
limited, yet this tissue is severely affected by ageing in humans. Methods We conducted a …
Resistance training rejuvenates the mitochondrial methylome in aged human skeletal muscle
Resistance training (RT) alters skeletal muscle nuclear DNA methylation patterns (or the
methylome). However, no study has examined if RT affects the mitochondrial DNA (mtDNA) …
methylome). However, no study has examined if RT affects the mitochondrial DNA (mtDNA) …
An epigenetic clock for human skeletal muscle
Background Ageing is associated with DNA methylation changes in all human tissues, and
epigenetic markers can estimate chronological age based on DNA methylation patterns …
epigenetic markers can estimate chronological age based on DNA methylation patterns …
Lifelong physical activity is associated with promoter hypomethylation of genes involved in metabolism, myogenesis, contractile properties and oxidative stress …
Lifelong regular physical activity is associated with reduced risk of type 2 diabetes (T2D),
maintenance of muscle mass and increased metabolic capacity. However, little is known …
maintenance of muscle mass and increased metabolic capacity. However, little is known …
Aerobic exercise training resets the human skeletal muscle methylome 10 years after breast cancer treatment and survival
Cancer survivors suffer impairments in skeletal muscle in terms of reduced mass and
function. Interestingly, human skeletal muscle possesses an epigenetic memory of earlier …
function. Interestingly, human skeletal muscle possesses an epigenetic memory of earlier …
Sex differences in muscle protein expression and DNA methylation in response to exercise training
Background Exercise training elicits changes in muscle physiology, epigenomics,
transcriptomics, and proteomics, with males and females exhibiting differing physiological …
transcriptomics, and proteomics, with males and females exhibiting differing physiological …