Cellular senescence occurs in response to endogenous or exogenous stresses and is
characterized by stable cell cycle arrest, alterations in nuclear morphology and secretion of …

Cellular senescence was first described as a state characterized by telomere shortening,
resulting in limiting cell proliferation in aging. Apart from this type of senescence, which is …

Cell senescence, the senescence-associated secretory phenotype, and cancers | PLOS Biology
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Cellular senescence is a state of stable, terminal cell cycle arrest associated with various
macromolecular changes and a hypersecretory, pro-inflammatory phenotype. Entry of cells …

Cellular senescence, an eternal condition of cell cycle arrest due to cellular stressors, is a
sign of aging. Senescent cells (SCs) build up in tissues as they age, impairing their ability to …

Senescent cells are found to accumulate in aged individuals, as well as in cancer patients
that receive chemotherapeutic treatment. Although originally believed to halt cancer …

Aging is a life phenomenon that occurs in most living organisms and is a major risk factor for
many diseases, including cancer. Cellular senescence is a cellular trait induced by various …

The concept of geroscience is that since ageing is the greatest risk factor for many diseases
and conditions, targeting the ageing process itself will have the greatest impact on human …

Cellular senescence is a primary aging process and tumor suppressive mechanism
characterized by irreversible growth arrest, apoptosis resistance, production of a …

Aging is the most important single risk factor for many chronic diseases such as cancer,
metabolic syndrome, and neurodegenerative disorders. Targeting aging itself might …