Evidence indicates that anxiety disorders arise from an imbalance in the functioning of brain
circuits that govern the modulation of emotional responses to possibly threatening stimuli …

Several converging lines of evidence from molecular, animal, and clinical studies have
demonstrated that the gamma-aminobutyric type A (GABAA) receptor complex plays a …

Publisher Summary This chapter demonstrates that molecular biology of GABA A receptors
in the central nervous system (CNS) has demonstrated remarkable heterogeneity in the …

GABAergic neurotransmission in the amygdala plays a crucial role in mediating emotional
learning, fear, and memory. In this study, expression of five major GABA A receptor subunits …

ANXIETY IS a behavioral state common to everyday life. Anxiety can be conceived as the
cognitive manifestation of an 'alarming'or 'alerting'system serving to prepare the organism for …

Lines of evidence coming from many branches of neuroscience indicate that anxiety
disorders arise from a dysfunction in the modulation of brain circuits which regulate …

GABA is one of the principal inhibitory neurotransmitters in the mammalian brain and an
ever increasing wealth of information suggests that GABAergic mechanisms have a special …

Mice with point-mutated α2 GABAA receptor subunits (rendering them diazepam insensitive)
are resistant to the anxiolytic-like effects of benzodiazepines (BZs) in the conditioned …

Mechanisms underlying the pathological characteristics of the various anxiety disorders
have yet to be fully elucidated. One of the most widely accepted mediators known to play a …

Rationale Emerging data support a role for GABA B receptors in anxiety. GABA B receptors
are comprised of a heterodimeric complex of GABA B1 and GABA B2 receptor subunits. The …