Validation of biomarkers of aging

M Moqri, C Herzog, JR Poganik, K Ying, JN Justice… - Nature Medicine, 2024 - nature.com
The search for biomarkers that quantify biological aging (particularly 'omic'-based
biomarkers) has intensified in recent years. Such biomarkers could predict aging-related …

Biomarkers of aging for the identification and evaluation of longevity interventions

M Moqri, C Herzog, JR Poganik, J Justice, DW Belsky… - Cell, 2023 - cell.com
With the rapid expansion of aging biology research, the identification and evaluation of
longevity interventions in humans have become key goals of this field. Biomarkers of aging …

Biomarkers of ageing: Current state‐of‐art, challenges, and opportunities

R Chen, Y Wang, S Zhang, G Bulloch… - MedComm–Future …, 2023 - Wiley Online Library
Given the unprecedented phenomenon of population ageing, studies have increasing
captured the heterogeneity within the ageing process. In this context, the concept of …

Endpoints for geroscience clinical trials: health outcomes, biomarkers, and biologic age

SR Cummings, SB Kritchevsky - GeroScience, 2022 - Springer
Treatments that target fundamental processes of aging are expected to delay several aging-
related conditions simultaneously. Testing the efficacy of these treatments for potential anti …

The Aging Biomarker Consortium represents a new era for aging research in China

J Ren, M Song, W Zhang, JP Cai, F Cao, Z Cao… - Nature Medicine, 2023 - nature.com
The global population of older peo-ple is growing at an unprecedented rate, with the number
of people over 65 years of age expected to reach 1.6 billion by 2050. Given that aging is a …

Promising biomarkers of human aging: In search of a multi-omics panel to understand the aging process from a multidimensional perspective

NA Rivero-Segura, OY Bello-Chavolla… - Ageing research …, 2020 - Elsevier
The aging process has been linked to the occurrence of chronic diseases and functional
impairments, including cancer, sarcopenia, frailty, metabolic, cardiovascular, and …

A proposed panel of biomarkers of healthy ageing

J Lara, R Cooper, J Nissan, AT Ginty, KT Khaw… - BMC medicine, 2015 - Springer
Background There is no criterion reference for assessing healthy ageing and this creates
difficulties when conducting and comparing research on ageing across studies. A cardinal …

A framework for selection of blood-based biomarkers for geroscience-guided clinical trials: report from the TAME Biomarkers Workgroup

JN Justice, L Ferrucci, AB Newman, VR Aroda… - Geroscience, 2018 - Springer
Recent advances indicate that biological aging is a potentially modifiable driver of late-life
function and chronic disease and have led to the development of geroscience-guided …

Healthy aging: the ultimate preventative medicine

M Kaeberlein, PS Rabinovitch, GM Martin - Science, 2015 - science.org
Age is the greatest risk factor for nearly every major cause of mortality in developed nations.
Despite this, most biomedical research focuses on individual disease processes without …

Revisiting the hallmarks of aging to identify markers of biological age

F Guerville, P De Souto Barreto, I Ader… - The Journal of …, 2020 - Springer
The Geroscience aims at a better understanding of the biological processes of aging, to
prevent and/or delay the onset of chronic diseases and disability as well as to reduce the …