In the first days of life, cells of the mammalian embryo segregate into two distinct lineages,
trophectoderm and inner cell mass. Unlike nonmammalian species, mammalian …

During mouse preimplantation embryo development, totipotent blastomeres generate the
first three cell lineages of the embryo: trophectoderm, epiblast and primitive endoderm. In …

The divergence of two differentiating extraembryonic cell types (trophectoderm and primitive
endoderm) from the pluripotent epiblast population (the source of fetal progenitor cells) by …

The inside-outside model has been invoked to explain cell-fate specification of the pre-
implantation mammalian embryo. Here, we investigate whether cell-cell interaction can …

Preimplantation development in mammals encompasses a period from fertilization to
implantation and results in formation of a blastocyst composed of three distinct cell lineages …

In early mouse embryos the first cell-fate decision segregates two cell populations: the outer
trophectoderm (TE) and inner cell mass (ICM). Cells are primarily directed to the ICM in two …

The first stages of mammalian development, before implantation of the embryo in the
maternal uterus, result in the establishment of three cell populations in the blastocyst …

There is a long-running controversy about how early cell fate decisions are made in the
developing mammalian embryo., In particular, it is controversial when the first events that …

Before the mammalian embryo is ready to implant in the uterine wall, the single cell zygote
must divide and differentiate into three distinct tissues; trophectoderm (prospective …

During mammalian pre-implantation embryo development, when the first asymmetry
emerges and how it develops to direct distinct cell fates remain longstanding questions …