A Comprehensive Performance Comparison Study of Various Statistical Models that Accommodate Challenges of the Gut Microbiome Data

M Hajihosseini, P Amini, A Saidi-Mehrabad… - Statistics in …, 2024 - Springer
The human gut microbiome refers to trillions of symbiotic bacteria that colonize the human
gut after birth, having an essential role in maintaining human health. Various factors can …

[HTML][HTML] Infants' gut microbiome data: A Bayesian Marginal Zero-inflated Negative Binomial regression model for multivariate analyses of count data

M Hajihosseini, P Amini, A Saidi-Mehrabad… - Computational and …, 2023 - Elsevier
The infants' gut microbiome is dynamic in nature. Literature has shown high inter-individual
variability of gut microbial composition in the early years of infancy compared to adulthood …

[HTML][HTML] metamicrobiomeR: an R package for analysis of microbiome relative abundance data using zero-inflated beta GAMLSS and meta-analysis across studies …

NT Ho, F Li, S Wang, L Kuhn - BMC bioinformatics, 2019 - Springer
Background The rapid growth of high-throughput sequencing-based microbiome profiling
has yielded tremendous insights into human health and physiology. Data generated from …

[图书][B] Statistical analysis of microbiome data with R

Y Xia, J Sun, DG Chen - 2018 - Springer
Microbiome research and microbiome data analysis are one of the fast-growing areas in
biomedical and public health research. It is evidenced and catalyzed by publications in …

[HTML][HTML] Comparative analysis of microbiome measurement platforms using latent variable structural equation modeling

X Wu, K Berkow, DN Frank, E Li, AS Gulati, W Zhu - BMC bioinformatics, 2013 - Springer
Background Culture-independent phylogenetic analysis of 16S ribosomal RNA (rRNA) gene
sequences has emerged as an incisive method of profiling bacteria present in a specimen …

[HTML][HTML] Statistical and machine learning techniques in human microbiome studies: contemporary challenges and solutions

I Moreno-Indias, L Lahti, M Nedyalkova… - Frontiers in …, 2021 - frontiersin.org
The human microbiome has emerged as a central research topic in human biology and
biomedicine. Current microbiome studies generate high-throughput omics data across …

[HTML][HTML] Hypothesis testing and statistical analysis of microbiome

Y Xia, J Sun - Genes & diseases, 2017 - Elsevier
After the initiation of Human Microbiome Project in 2008, various biostatistic and
bioinformatic tools for data analysis and computational methods have been developed and …

A comparison of bioinformatics pipelines for compositional analysis of the human gut microbiome

J Szopinska-Tokov, M Bloemendaal, J Boekhorst… - bioRxiv, 2023 - biorxiv.org
Investigating the impact of gut microbiome on human health is a rapidly growing area of
research. A significant limiting factor in the progress in this field is the lack of consistency …

[HTML][HTML] Beyond samples: A metric revealing more connections of gut microbiota between individuals

Z Yang, F Xu, H Li, Y He - Computational and Structural Biotechnology …, 2021 - Elsevier
Studies of gut microbiota explore their complicated connections between individuals of
different characteristics by applying different metrics to abundance data obtained from fecal …

Improved methods for understanding the human gut microbiome

JW Debelius - 2015 - search.proquest.com
The gut microbiome plays a profound role in human health. Over the last decade, much work
has been done to define differences between microbial communities in healthy and …