Generation of liver tissue-resident memory T cells with novel NKT cell agonists and mRNA vaccines

M Ganley - 2024 - openaccess.wgtn.ac.nz
mRNA vaccines have become a central part of vaccine research over the last decade due to
their application in cancer immunotherapy, and more recently, the rapid response to the …

Complexing CpG adjuvants with cationic liposomes enhances vaccine-induced formation of liver TRM cells

AM Valencia-Hernandez, T Zillinger, Z Ge, PS Tan… - Vaccine, 2023 - Elsevier
Tissue resident memory T cells (T RM cells) can provide effective tissue surveillance and
can respond rapidly to infection. Vaccination strategies aimed at generating T RM cells have …

Glycolipid-peptide vaccination induces liver-resident memory CD8+ T cells that protect against malaria

L Holz, YC Chua, RJ Anderson, S Draper… - The Journal of …, 2019 - journals.aai.org
Liver resident-memory CD8+ T cells (T RM cells) provide important protection against liver-
stage Plasmodium infections. Here, we show that a glycolipid-peptide conjugate vaccine …

Harnessing liver-resident memory T cells for protection against malaria

D Fernandez-Ruiz, MN de Menezes… - Expert Review of …, 2021 - Taylor & Francis
Introduction Tissue-resident memory T cells (TRM cells) are powerful mediators of protracted
adaptive immunity to infection in peripheral organs. Harnessing TRM cells through …

Tissue-Resident memory T cells in the Liver—Unique characteristics of local specialists

LM Bartsch, MPS Damasio, S Subudhi, HK Drescher - Cells, 2020 - mdpi.com
T cells play an important role to build up an effective immune response and are essential in
the eradication of pathogens. To establish a long-lasting protection even after a re-challenge …

Inducing immunity to liver stage malaria through endogenous tissue resident memory cells

AM Valencia Hernandez - 2020 - bonndoc.ulb.uni-bonn.de
Tissue-resident memory CD8 T (TRM) cells provide effective tissue surveillance and can
respond rapidly to infection due to their strategic location. Within the liver, TRM cells can …

Cutting Edge: Optimal Formation of Hepatic Tissue-Resident Memory CD4 T Cells Requires T-bet Regulation of CD18

CE Depew, AT Nguyen, MC Franke… - The Journal of …, 2023 - journals.aai.org
CD4 tissue-resident memory T cells (TRMs) allow robust protection of barrier surfaces
against pathogens. We investigated the role of T-bet in the formation of liver CD4 TRMs …

Glycolipid-peptide vaccination induces liver-resident memory CD8+ T cells that protect against rodent malaria

LE Holz, YC Chua, MN de Menezes, RJ Anderson… - Science …, 2020 - science.org
Liver resident-memory CD8+ T cells (TRM cells) can kill liver-stage Plasmodium-infected
cells and prevent malaria, but simple vaccines for generating this important immune …

Prime-and-trap malaria vaccination to generate protective CD8+ liver-resident memory T cells

TM Olsen, BC Stone, V Chuenchob… - The Journal of …, 2018 - journals.aai.org
Tissue-resident memory CD8+ T (Trm) cells in the liver are critical for long-term protection
against pre-erythrocytic Plasmodium infection. Such protection can usually be induced with …

Tissue-resident memory T cells in chronic liver diseases: Phenotype, development and function

Y Li, Z You, R Tang, X Ma - Frontiers in Immunology, 2022 - frontiersin.org
Tissue-resident memory (TRM) T cells are a unique subset of memory T cells that are critical
for the first line of defense against pathogens or antigens in peripheral non-lymphoid tissues …