The immune system is built to counteract unpredictable threats, yet it relies on predictable
cycles of activity to function properly. Daily rhythms in immune function are an expanding …

Circadian rhythms are a ubiquitous feature of virtually all living organisms, regulating a wide
diversity of physiological systems. It has long been established that the circadian clockwork …

The circadian system ensures the generation and maintenance of self-sustained∼ 24-h
rhythms in physiology that are linked to internal and environmental changes. In mammals …

From bacteria to mammals, nearly all organisms have adapted their physiology and
behavior to a daily rhythm. These circadian (daily) rhythms influence virtually all aspects of …

Abstract Purpose of Review This review is focused on the existing evidence for circadian
control of innate and adaptive immune responses to provide a framework for evaluating the …

Development of inflammatory diseases, such as metabolic syndrome and cancer, is
prevalent in individuals that encounter continuous disruption of their internal clock. Further …

Circadian rhythms, which have long been known to play crucial roles in physiology, are
emerging as important regulators of specific immune functions. Circadian oscillations of …

There is increasing evidence that the immune system is regulated by circadian rhythms. A
wide range of immune parameters, such as the number of red blood cells and peripheral …

Immune responses are gated to protect the host against specific antigens and microbes, a
task that is achieved through antigen-and pattern-specific receptors. Less appreciated is that …

The immune system is highly time-of-day dependent. Pioneering studies in the 1960s were
the first to identify immune responses to be under a circadian control. Only in the last …