Access to DNA is the first level of control in regulating gene transcription, a control that is
also critical for maintaining DNA integrity. Cellular senescence is characterized by profound …

Background Cellular senescence is a permanent state of replicative arrest defined by a
specific pattern of gene expression. The epigenome in senescent cells is sculptured in order …

DNA double-strand break (DSB) repair occurs within chromatin and can be modulated by
chromatin-modifying enzymes. Here we identify the related human histone deacetylases …

Abstract Histone deacetylase 6 (HDAC6) mediates DNA damage signaling by regulating the
mismatch repair and nucleotide excision repair pathways. Whether HDAC6 also mediates …

Protein acetylation is mediated by histone acetyltransferases (HATs) and deacetylases
(HDACs), which influence chromatin dynamics, protein turnover and the DNA damage …

Both the DNA damage response (DDR) and epigenetic mechanisms play key roles in the
implementation of senescent phenotypes, but very little is known about how these two …

Histone deacetylases 1 and 2 (HDAC1, 2) belong to the class I HDAC family, which are
targeted by the FDA-approved small molecule HDAC inhibitors currently used in cancer …

Expression of the class II a HDAC s is frequently altered in different human cancers. In
mouse models these transcriptional repressors can trigger transformation, acting as bona …

DNA damage triggers diverse cancers, particularly hepatocellular carcinoma (HCC), but the
intrinsic link between DNA damage and tumorigenesis remains unclear. Because of its role …

Abstract Histone deacetylase 2 (HDAC2) is relevant for homeostasis and plays a critical role
in gastrointestinal cancers. Here, we report that post-translational modification of …