Chemical discovery efforts commonly target individual protein domains. Many proteins,
including the EP300/CBP histone acetyltransferases (HATs), contain several targetable …

Bromodomain and extra-terminal domain (BET) proteins, cyclic adenosine monophosphate
response element-binding protein (CBP), and the E1A-binding protein of p300 (EP300) are …

CREB binding protein (CBP) and E1A binding protein p300 (EP300) are paralog histone
acetyltransferases involved in many cellular processes via their activity as transcription …

CBP (CREB (cAMP responsive element binding protein) binding protein (CREBBP)) and
P300 (adenovirus E1A-associated 300 kDa protein) are two closely related histone …

The dynamic and reversible acetylation of proteins, catalysed by histone acetyltransferases
(HATs) and histone deacetylases (HDACs), is a major epigenetic regulatory mechanism of …

CBP and EP300 are highly homologous, bromodomain-containing transcription coactivators
involved in numerous cellular pathways relevant to oncology. As part of our effort to explore …

EP300/CBP are histone acetyltransferases recruited onto chromatin by oncogenic
transcription factors and control the transcriptional program via their activity in enhancer …

Medulloblastoma is a highly malignant paediatric brain tumour, often inflicting devastating
consequences on the developing child. Genomic studies have revealed four distinct …

Current therapies for medulloblastoma, a highly malignant childhood brain tumour, impose
debilitating effects on the developing child, and highlight the need for molecularly targeted …

Childhood ependymomas are heterogenous chemoresistant neoplasms arising from
aberrant stem-like cells. Epigenome deregulation plays a pivotal role in ependymoma …