Epigenetic changes are known to accrue in normal cells as a result of ageing and
cumulative exposure to cancer risk factors. Increasing evidence points towards age-related …

It is well-established that the DNA methylation landscape of normal cells undergoes a
gradual modification with age, termed as 'epigenetic drift'. Here, we review the current state …

The concept of an epigenetic landscape describing potential cellular fates arising from
pluripotent cells, first advanced by Conrad Waddington, has evolved in light of experiments …

In this Perspective, we synthesize past and present observations in the field of epigenetics to
propose a model in which the epigenome can modulate cellular plasticity in development …

It is now well established that the genomic landscape of DNA methylation (DNAm) gets
altered as a function of age, a process we here call 'epigenetic drift'. The biological …

Editorial Langevin, Pinney, Leung & Ho a cytosine in a gene promoter may not exert an
obvious effect on gene expression, the random accumulation (or loss) of several such marks …

The incidence of cancer, adjusted for secular trends, is directly related to age, and advanced
chronologic age is one of the most significant risk factors for cancer. Organismal aging is …

Ageing mammals are subject to an amazing array of aberrations in proliferative
homeostasis. These are of two basic types: the post-maturational failure to adequately …

Accumulation of somatic mutations and genomic instability are hallmarks of both aging and
cancer. Epigenetic alterations occur across cell types and tissues with advancing age. DNA …

Intratumor heterogeneity is a key hallmark of cancer that contributes to progression and
therapeutic resistance. Phenotypic heterogeneity is in part caused by Darwinian selection of …