Highlights•Comprehensive TME characterization is required to understand therapy
resistance and sensitivity to current generations of therapeutics•Spatial profiling has …

The tumor microenvironment (TME) is composed of many different cellular and acellular
components that together drive tumor growth, invasion, metastasis, and response to …

The tumor microenvironment (TME) is a heterogeneous milieu of cellular and molecular
factors that play a crucial role in tumor evolution and disease progression. These factors are …

During the second half of the twentieth century, oncology adopted a tumor-centric approach
to cancer treatment, focusing primarily on the tumor cell to identify new therapeutic targets …

Interpreting the mechanisms and principles that govern gene activity and how these genes
work according to-their cellular distribution in organisms has profound implications for …

Despite the tremendous clinical successes recorded in the landscape of cancer therapy,
tumor heterogeneity remains a formidable challenge to successful cancer treatment. In …

Visualization of the cellular heterogeneity and spatial architecture of the tumor
microenvironment (TME) is becoming increasingly important to understand mechanisms of …

Growing evidence supports the critical role of tumour microenvironment (TME) in tumour
progression, metastases, and treatment response. However, the in-situ interplay among …

Cancer cells all share the feature of being immersed in a complex environment with altered
cell-cell/cell-extracellular element communication, physicochemical information, and tissue …

Cancer research has witnessed remarkable advancements in recent years, with molecularly
targeted treatments and immunotherapy revolutionizing patient care. However, some cancer …