Platelet-Rich Plasma in Young and Elderly Humans Exhibits a Different Proteomic Profile

Z Jiang, C Huang, E Guo, X Zhu, N Li… - Journal of Proteome …, 2024 - ACS Publications
As people age, their ability to resist injury and repair damage decreases significantly.
Platelet-rich plasma (PRP) has demonstrated diverse therapeutic effects on tissue repair …

[HTML][HTML] Proteomic analysis of platelet-rich and platelet-poor plasma

O Miroshnychenko, RJ Chalkley, RD Leib, PA Everts… - Regenerative …, 2020 - Elsevier
Background Autologous blood products, such as platelet-rich plasma (PRP) are commercial
products broadly used to accelerate healing of tissues after injuries. However, their content …

The Perspectives of Platelet Proteomics in Health and Disease

PK Chaudhary, S Upadhayaya, S Kim, S Kim - Biomedicines, 2024 - mdpi.com
Cardiovascular thromboembolic diseases and cancer continue to be a leading cause of
death and disability worldwide. Therefore, it is crucial to advance their diagnoses and …

Proteomic classification and identification of proteins related to tissue healing of platelet-rich plasma

HW Lee, KH Choi, JY Kim, KO Kim… - Clinics in …, 2020 - synapse.koreamed.org
Background Platelet-rich plasma (PRP) is a plasma component of autologous blood
containing a high concentration of platelets. PRP is used to promote healing of damaged …

Platelet proteome changes associated with diabetes and during platelet storage for transfusion

DL Springer, JH Miller, SL Spinelli… - Journal of proteome …, 2009 - ACS Publications
Human platelets play a key role in hemostasis and thrombosis and have recently emerged
as key regulators of inflammation. Platelets stored for transfusion produce pro-thrombotic …

[HTML][HTML] Proteome and functional decline as platelets age in the circulation

HE Allan, MA Hayman, S Marcone, MV Chan… - Journal of Thrombosis …, 2021 - Elsevier
Background Platelets circulate in the blood of healthy individuals for approximately 7–10
days regulated by finely balanced processes of production and destruction. As platelets are …

Global analysis of the rat and human platelet proteome–the molecular blueprint for illustrating multi‐functional platelets and cross‐species function evolution

Y Yu, T Leng, D Yun, N Liu, J Yao, Y Dai, P Yang… - …, 2010 - Wiley Online Library
Emerging evidences indicate that blood platelets function in multiple biological processes
including immune response, bone metastasis and liver regeneration in addition to their …

Unraveling the signaling secretome of platelet-rich plasma: towards a better understanding of its therapeutic potential in knee osteoarthritis

C Del Amo, A Perez-Valle, L Atilano… - Journal of Clinical …, 2022 - mdpi.com
Platelets and their secretory products play an important role in determining the balance
between tissue repair and tissue damage. To obtain novel insights into the molecular …

Anti-Aging Potential of Platelet Rich Plasma (PRP): Evidence from Osteoarthritis (OA) and Applications in Senescence and Inflammaging

J Vun, N Iqbal, E Jones, P Ganguly - Bioengineering, 2023 - mdpi.com
Aging and age-related changes impact the quality of life (QOL) in elderly with a decline in
movement, cognitive abilities and increased vulnerability towards age-related diseases …

Leukocyte‐Rich Platelet‐Rich Plasma as an Effective Source of Molecules That Modulate Local Immune and Inflammatory Cell Responses

M Dejnek, H Moreira, S Płaczkowska… - Oxidative Medicine …, 2022 - Wiley Online Library
Autologous platelet‐rich plasma (PRP) injection is a safe biological method used to treat
various musculoskeletal diseases. By downregulation of inflammatory cytokines and …