[HTML][HTML] The global impact of COVID-19 on solid organ transplantation: two years into a pandemic
A Nimmo, D Gardiner, I Ushiro-Lumb, R Ravanan… - …, 2022 - journals.lww.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic has had a major global
impact on solid organ transplantation (SOT). An estimated 16% global reduction in …
impact on solid organ transplantation (SOT). An estimated 16% global reduction in …
Safety, tolerability, and pharmacokinetics of VV116, an oral nucleoside analog against SARS-CoV-2, in Chinese healthy subjects
H Qian, Y Wang, M Zhang, Y Xie, Q Wu… - Acta Pharmacologica …, 2022 - nature.com
Abstract VV116 (JT001) is an oral drug candidate of nucleoside analog against SARS-CoV-
2. The purpose of the three phase I studies was to evaluate the safety, tolerability, and …
2. The purpose of the three phase I studies was to evaluate the safety, tolerability, and …
Combination of antiviral drugs inhibits SARS-CoV-2 polymerase and exonuclease and demonstrates COVID-19 therapeutic potential in viral cell culture
X Wang, CQ Sacramento, S Jockusch… - Communications …, 2022 - nature.com
SARS-CoV-2 has an exonuclease-based proofreader, which removes nucleotide inhibitors
such as Remdesivir that are incorporated into the viral RNA during replication, reducing the …
such as Remdesivir that are incorporated into the viral RNA during replication, reducing the …
Treatments for COVID-19
HS Andrews, JD Herman… - Annual Review of …, 2024 - annualreviews.org
The treatment for COVID-19 has evolved rapidly since the start of the pandemic and now
consists mainly of antiviral and immunomodulatory agents. Antivirals, such as remdesivir …
consists mainly of antiviral and immunomodulatory agents. Antivirals, such as remdesivir …
Efficacy and safety of nirmatrelvir/ritonavir, molnupiravir, and remdesivir in a real-world cohort of outpatients with COVID-19 at high risk of progression: the PISA …
G Tiseo, C Barbieri, V Galfo, S Occhineri… - Infectious Diseases and …, 2023 - Springer
Introduction Different antivirals are available for the treatment of outpatients with COVID-19.
Our aim was to describe a real-world experience of outpatient management of COVID-19 …
Our aim was to describe a real-world experience of outpatient management of COVID-19 …
SARS-CoV-2 cell entry beyond the ACE2 receptor
SD Alipoor, M Mirsaeidi - Molecular biology reports, 2022 - Springer
Background Angiotensin-converting enzyme 2 (ACE2) is known as the major viral entry site
for SARS-CoV-2. However, viral tissue tropism and high rate of infectivity do not directly …
for SARS-CoV-2. However, viral tissue tropism and high rate of infectivity do not directly …
Effect of fluvoxamine vs placebo on time to sustained recovery in outpatients with mild to moderate COVID-19: a randomized clinical trial
Importance The effectiveness of fluvoxamine to shorten symptom duration or prevent
hospitalization among outpatients with mild to moderate symptomatic COVID-19 is unclear …
hospitalization among outpatients with mild to moderate symptomatic COVID-19 is unclear …
Outcomes with and without outpatient SARS-CoV-2 treatment for patients with COVID-19 and systemic autoimmune rheumatic diseases: a retrospective cohort study
Background Some patients with systemic autoimmune rheumatic disease and
immunosuppression might still be at risk of severe COVID-19. The effect of outpatient SARS …
immunosuppression might still be at risk of severe COVID-19. The effect of outpatient SARS …
Green adherent spectrophotometric determination of molnupiravir based on computational calculations; application to a recently FDA-approved pharmaceutical …
AH Abdelazim, MAS Abourehab… - … Acta Part A: Molecular …, 2023 - Elsevier
Molnupiravir is an oral antiviral drug developed to provide significant benefit in reducing
hospitalizations or deaths in mild COVID-19. Integrated green computational …
hospitalizations or deaths in mild COVID-19. Integrated green computational …
[PDF][PDF] Preparing for the next viral threat with broad-spectrum antivirals
There is a large global unmet need for the development of countermeasures to combat
hundreds of viruses known to cause human disease and for the establishment of a …
hundreds of viruses known to cause human disease and for the establishment of a …