New perspectives on antimicrobial agents: molnupiravir and nirmatrelvir/ritonavir for treatment of COVID-19

RL Atmar, N Finch - Antimicrobial Agents and Chemotherapy, 2022 - Am Soc Microbiol
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has emerged to cause
pandemic respiratory disease in the past 2 years, leading to significant worldwide morbidity …

[HTML][HTML] Protein structure-based in-silico approaches to drug discovery: Guide to COVID-19 therapeutics

Y Gupta, OV Savytskyi, M Coban, A Venugopal… - Molecular Aspects of …, 2023 - Elsevier
With more than 5 million fatalities and close to 300 million reported cases, COVID-19 is the
first documented pandemic due to a coronavirus that continues to be a major health …

Safety and efficacy of molnupiravir in SARS‐CoV‐2‐infected patients: A real‐life experience

A De Vito, A Colpani, A Bitti, B Zauli… - Journal of Medical …, 2022 - Wiley Online Library
Since the start of the severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2)
pandemic, several treatments have been proposed to cure coronavirus disease 2019 …

Neutralization of SARS-CoV-2 Omicron BA. 2 by therapeutic monoclonal antibodies

H Zhou, T Tada, BM Dcosta, NR Landau - Biorxiv, 2022 - ncbi.nlm.nih.gov
Monoclonal antibody therapy for the treatment of SARS-CoV-2 infection has been highly
successful in decreasing disease severity; however, the recent emergence of the heavily …

Real-world effectiveness of molnupiravir, nirmatrelvir-ritonavir, and sotrovimab on preventing hospital admission among higher-risk patients with COVID-19 in Wales …

A Evans, C Qi, JO Adebayo, J Underwood, J Coulson… - Journal of Infection, 2023 - Elsevier
Objective To compare the effectiveness of molnupiravir, nirmatrelvir-ritonavir, and
sotrovimab with no treatment in preventing hospital admission or death in higher-risk …

[HTML][HTML] Impact of COVID-19 on cardiovascular disease

I Vosko, A Zirlik, H Bugger - Viruses, 2023 - mdpi.com
Coronavirus disease 2019 (COVID-19) is a viral infection with the novel severe acute
respiratory distress syndrome corona virus 2 (SARS-CoV-2). Until now, more than 670 …

[HTML][HTML] Characterisation of SARS-CoV-2 genomic variation in response to molnupiravir treatment in the AGILE Phase IIa clinical trial

I Donovan-Banfield, R Penrice-Randal… - Nature …, 2022 - nature.com
Molnupiravir is an antiviral, currently approved by the UK Medicines and Healthcare
products Regulatory Agency (MHRA) for treating at-risk COVID-19 patients, that induces …

[HTML][HTML] Resistance to nirmatrelvir due to mutations in the Mpro in the subvariants of SARS-CoV-2 Omicron: Another concern?

S Chatterjee, M Bhattacharya, K Dhama, SS Lee… - … Therapy-Nucleic Acids, 2023 - cell.com
The world has faced 3 years of the COVID-19 pandemic with billions of infections, millions of
deaths, and a massive economic crisis. Since the pandemic began, scientists have started to …

[HTML][HTML] Impact of early SARS-CoV-2 antiviral therapy on disease progression

A De Vito, A Colpani, L Saderi, M Puci, B Zauli, V Fiore… - Viruses, 2022 - mdpi.com
Since the start of the SARS-CoV-2 pandemic, several treatments have been proposed to
prevent the progression of the disease. Currently, three antiviral (molnupiravir, nirmaltrevir/r …

Anti–SARS-CoV-2 pharmacotherapies among nonhospitalized US veterans, January 2022 to January 2023

L Yan, E Streja, Y Li, N Rajeevan, M Rowneki… - JAMA Network …, 2023 - jamanetwork.com
Importance Several pharmacotherapies have been authorized to treat nonhospitalized
persons with symptomatic COVID-19. Longitudinal information on the use of these therapies …