Role of neuroinflammation in neurodegeneration development

W Zhang, D Xiao, Q Mao, H Xia - Signal transduction and targeted …, 2023 - nature.com
Studies in neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease
and Amyotrophic lateral sclerosis, Huntington's disease, and so on, have suggested that …

Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes

HS Kwon, SH Koh - Translational neurodegeneration, 2020 - Springer
Neuroinflammation is associated with neurodegenerative diseases, such as Alzheimer's
disease, Parkinson's disease, and amyotrophic lateral sclerosis. Microglia and astrocytes …

Plasma GFAP is an early marker of amyloid-β but not tau pathology in Alzheimer's disease

JB Pereira, S Janelidze, R Smith, N Mattsson-Carlgren… - Brain, 2021 - academic.oup.com
Although recent clinical trials targeting amyloid-β in Alzheimer's disease have shown
promising results, there is increasing evidence suggesting that understanding alternative …

Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain

J Marschallinger, T Iram, M Zardeneta, SE Lee… - Nature …, 2020 - nature.com
Microglia become progressively activated and seemingly dysfunctional with age, and
genetic studies have linked these cells to the pathogenesis of a growing number of …

Cellular senescence and Alzheimer disease: the egg and the chicken scenario

S Saez-Atienzar, E Masliah - Nature Reviews Neuroscience, 2020 - nature.com
Globally, 50 million people live with dementia, with Alzheimer disease (AD) being
responsible for two-thirds of the total cases. As ageing is the main risk factor for dementia …

Mitochondrial dysfunctions, oxidative stress and neuroinflammation as therapeutic targets for neurodegenerative diseases: an update on current advances and …

MU Rehman, N Sehar, NJ Dar, A Khan, A Arafah… - Neuroscience & …, 2023 - Elsevier
Neurodegenerative diseases (NDs) such as Alzheimer disease (AD), Parkinson disease
(PD), and Huntington disease (HD) represent a major socio-economic challenge in view of …

Exercise suppresses neuroinflammation for alleviating Alzheimer's disease

M Wang, H Zhang, J Liang, J Huang… - Journal of …, 2023 - Springer
Alzheimer's disease (AD) is a chronic neurodegenerative disease, with the characteristics of
neurofibrillary tangle (NFT) and senile plaque (SP) formation. Although great progresses …

GBA, Gaucher Disease, and Parkinson's Disease: From Genetic to Clinic to New Therapeutic Approaches

GM Riboldi, AB Di Fonzo - Cells, 2019 - mdpi.com
Parkinson's disease (PD) is the second most common degenerative disorder. Although the
disease was described more than 200 years ago, its pathogenetic mechanisms have not yet …

Alzheimer's disease: updated multi-targets therapeutics are in clinical and in progress

Z Sang, K Wang, J Dong, L Tang - European journal of medicinal chemistry, 2022 - Elsevier
Alzheimer's disease is a chronic and progressive brain neurodegenerative disease affecting
over 30 million people globally. Currently, no effective treatment is available due to multiple …

Immune signaling in neurodegeneration

TR Hammond, SE Marsh, B Stevens - Immunity, 2019 - cell.com
Neurodegenerative diseases of the central nervous system progressively rob patients of
their memory, motor function, and ability to perform daily tasks. Advances in genetics and …