Many of the internal organ systems of Drosophila melanogaster are functionally analogous
to those in vertebrates, including humans. Although humans and flies differ greatly in terms …

Despite the advances that have been made in developing new therapeutics, cardiovascular
disease remains the leading cause of worldwide mortality. Therefore, understanding the …

Insects are the most ecologically important multicellular heterotrophs in terrestrial systems.
They play critical roles in ecological food webs, remain devastating agricultural and medical …

Background—Atrial fibrillation (AF) is characterized by structural remodeling, contractile
dysfunction, and AF progression. Histone deacetylases (HDACs) influence acetylation of …

Mitochondrial fission and fusion have been observed, and their importance revealed, in
almost every tissue and cell type except adult cardiac myocytes. As each human heart is …

The fruit fly Drosophila melanogaster is increasingly utilized as an alternative to costly
rodent models to study human diseases. Fly models exist for a wide variety of human …

Obesity and metabolic syndrome are associated with an increased risk for lipotoxic
cardiomyopathy, which is strongly correlated with excessive accumulation of lipids in the …

The Drosophila heart has proven itself to be an excellent model for human cardiac
development and recent investigations suggest that it may serve as a model for human heart …

The heart of the fruit fly, Drosophila melanogaster, is a particularly suitable model for cardiac
studies. Optical coherence microscopy (OCM) captures in vivo cross-sectional videos of the …

A significant current challenge in human genetics is the identification of interacting genetic
loci mediating complex polygenic disorders. One of the best characterized polygenic …