Optogenetics is widely used to interrogate the neural circuits underlying disease and has
most recently been harnessed for therapeutic applications. The optogenetic toolkit consists …

Modern optogenetics can be tuned to evoke activity that corresponds to naturally occurring
local or global activity in timing, magnitude or individual-cell patterning. This outcome has …

There have been two recent revolutionary advances in neuroscience: First, genetically
encoded activity sensors have brought the goal of optical detection of single action …

The most common forms of acquired epilepsies arise following acute brain insults such as
traumatic brain injury, stroke, or central nervous system infections. Treatment is effective for …

Advances in optical manipulation and observation of neural activity have set the stage for
widespread implementation of closed-loop and activity-guided optical control of neural …

Introduction: Deep brain stimulation is a safe and effective neurointerventional technique for
the treatment of movement disorders. Electrical stimulation of subcortical structures may …

Epileptic seizures represent dysfunctional neural networks dominated by excessive and/or
hypersynchronous activity. Recent progress in the field has outlined two concepts regarding …

The cerebellum is best known for its role in controlling motor behaviors. However, recent
work supports the view that it also influences non-motor behaviors. The contribution of the …

Key points A key mechanistic concept in epilepsy is the dentate gate hypothesis, which
argues that the dentate gyrus protects hippocampal circuits from overexcitation and that a …

In many patients who suffer from epilepsies, recurrent epileptic seizures do not start at birth
but develop later in life. This holds particularly true for epilepsies with a focal seizure origin …