Infiltration of human melanomas with cytotoxic immune cells correlates with spontaneous
type I IFN activation and a favorable prognosis. Therapeutic blockade of immune-inhibitory …

Dendritic cells (DCs) are endowed with a unique potency to prime T cells, as well as to
orchestrate their expansion, functional polarization and effector activity in non-lymphoid …

To metastasize, a tumor cell must acquire abilities such as the capacity to colonize new
tissue and evade immune surveillance. Recent evidence suggests that microRNAs can …

We hypothesized that immune gene-related signatures would predict the presence of
unique histological features of lymphoid cell infiltrates in colorectal carcinoma (CRC) that …

Motivation: The receiver operator characteristic (ROC) curves are commonly used in
biomedical applications to judge the performance of a discriminant across varying decision …

PGC1α is a transcription factor coactivator that influences a majority of cellular metabolic
pathways. Abnormal expression of PGC1α is associated with several chronic diseases and …

Histone variants are emerging as key regulatory molecules in cancer. We report a unique
role for the H2A. Z isoform H2A. Z. 2 as a driver of malignant melanoma. H2A. Z. 2 is highly …

The tumor microenvironment is shaped by interactions between malignant cells and host
cells representing an integral component of solid tumors. Host cells, including elements of …

We generated mice deficient in Lon protease (LONP1), a major enzyme of the mitochondrial
quality control machinery. Homozygous deletion of Lonp1 causes early embryonic lethality …

Oncogene-driven metabolic rewiring is an adaptation to low nutrient and oxygen conditions
in the tumor microenvironment that enables cancer cells of diverse origin to hyperproliferate …