Melanoma is currently divided on a genetic level according to mutational status. However,
this classification does not optimally predict prognosis. In prior studies, we have defined …

Purpose: The incidence of malignant melanoma is increasing worldwide in fair-skinned
populations. Melanomas respond poorly to systemic therapy, and metastatic melanomas …

Inducible costimulator (ICOS), a member of the CD28 family of costimulatory molecules, is
upregulated on the surface of T cells following T cell activation and upon binding to its ligand …

Purpose: Polyinosinic-polycytidylic acid-poly-l-lysine carboxymethylcellulose (poly-ICLC), a
synthetic double-stranded RNA complex, is a ligand for toll-like receptor-3 and MDA-5 that …

Predicting the clinical outcome of cancer patients based on the expression of marker genes
in their tumors has received increasing interest in the past decade. Accurate predictors of …

Introduction: The promotion of antitumor response by targeting co-stimulatory B7 superfamily
members has become evident to create a new wave of cancer immunotherapy. Inducible Co …

Considering the benefits of immunotherapy in advanced melanoma, non–small cell lung
cancer, renal cell carcinoma, bladder cancers, and refractory Hodgkin lymphoma, we begin …

The interest in tumor-infiltrating lymphocytes (TILs) as a prognostic biomarker in breast
cancer has grown in recent years. Biomarkers must undergo comprehensive evaluation in …

Prediction of outcome for melanoma patients with surgically resected macroscopic nodal
metastases is very imprecise. We performed a comprehensive clinico-pathologic …

The peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α) is a
central modulator of cell metabolism. It regulates mitochondrial biogenesis and oxidative …