Update on Early-Life T Cells: Impact on Oral Rotavirus Vaccines

C Montenegro, F Perdomo-Celis, MA Franco - Viruses, 2024 - mdpi.com
Rotavirus infection continues to be a significant public health problem in developing
countries, despite the availability of several vaccines. The efficacy of oral rotavirus vaccines …

ImmunoPET imaging of TIGIT in the glioma microenvironment

SR Vincze, AP Jaswal, SC Frederico, M Nisnboym… - Scientific Reports, 2024 - nature.com
Glioblastoma (GBM) is the most common primary malignant brain tumor. Currently, there are
few effective treatment options for GBM beyond surgery and chemo-radiation, and even with …

Preservation of naïve phenotype CD4+ T cells after vaccination contributes to durable immunity

YG Pan, L Bartolo, R Xu, BV Patel, VI Zarnitsyna… - JCI …, 2024 - Am Soc Clin Investig
Memory T cells are conventionally associated with durable recall responses. In our
longitudinal analyses of CD4+ T cell responses to the yellow fever virus (YFV) vaccine by …

[HTML][HTML] Differentiation marker-negative CD4+ T cells persist after yellow fever virus vaccination and contribute to durable memory

YG Pan, L Bartolo, R Xu, B Patel, V Zarnitsyna, L Su - bioRxiv, 2024 - ncbi.nlm.nih.gov
Factors that contribute to durable immunological memory remain incompletely understood.
In our longitudinal analyses of CD4+ T cell responses to the yellow fever virus (YFV) vaccine …

Unsupervised generative AI discovers pan-leukocyte dysregulated pathways in single-cell lupus data

H Bolouri, K Cerosaletti, A Lacy-Hulbert - bioRxiv, 2024 - biorxiv.org
Comparisons of single-cell RNA-sequencing (scRNA-seq) data from healthy and diseased
tissues are widely used to identify cell-type-specific dysregulated genes, pathways, and …

[HTML][HTML] Cell fate decision in erythropoiesis: insights from multi-omics studies.

S Tur, CG Palii, M Brand - Experimental Hematology, 2024 - Elsevier
Every second, the body produces 2 million red blood cells through a process called
erythropoiesis. Erythropoiesis is hierarchical in that it results from a series of cell fate …

Highlight of 2023: Unraveling the complexity of T cell aging-insights from recent advances.

J Guo, Z Xue, L Wang - Immunology and Cell Biology, 2024 - europepmc.org
Unraveling the complexities of T cell aging is essential for developing targeted interventions
to enhance immune function in the elderly. This article for the Highlights of 2023 Series …