Discoidin Domain Receptors (DDRs) have recently emerged as non-integrin-type receptors
for collagen. The two mammalian gene products Discoidin Domain Receptor 1 and-2 …

Branching morphogenesis in the kidney is a tightly regulated, complex process and its
disruption potentially can lead to a broad spectrum of diseases, ranging from rare hereditary …

Recent advances in the generation of kidney organoids and the culture of primary nephron
progenitors from mouse and human have been based on knowledge of the molecular basis …

Excretion of uric acid, a compound of considerable medical importance, is largely
determined by the balance between renal secretion and reabsorption. The latter process …

Kidney development is based on differential cell-type-specific expression of a vast number
of genes. While multiple critical genes and pathways have been elucidated, a genome-wide …

The ureteric bud (UB) is an outgrowth of the Wolffian duct, which undergoes a complex
process of growth, branching, and remodeling, to eventually give rise to the entire urinary …

The observation that mice with a selective ablation of the androgen receptor (AR) in Sertoli
cells (SC)(SCARKO mice) display a complete block in meiosis supports the contention that …

The past decade has seen a proliferation of studies that employ quantitative trait locus (QTL)
approaches to diagnose the genetic basis of trait evolution. Advances in molecular …

SLIT-2 is considered as a candidate tumor suppressor gene, because it is frequently
inactivated in various cancers due to hypermethylation of its promoter region and allelic loss …

In search of guiding principles involved in the branching of epithelial tubes in the developing
kidney, we analyzed branching of the ureteric bud (UB) in whole kidney culture as well as in …