Genetic studies of Alzheimer disease (AD) have prioritized variants in genes related to the
amyloid cascade, lipid metabolism, and neuroimmune modulation. However, the cell …

Simultaneous measurement of multiple modalities in single-cell analysis, represented by
CITE-seq, is a promising approach to link transcriptional changes to cellular phenotype and …

Acute kidney injury (AKI) is a major risk factor for long-term adverse outcomes, including
chronic kidney disease. In mouse models of AKI, maladaptive repair of the injured proximal …

Abstract Background N6-methyladenosine (m6A) RNA methylation plays a critical role in key
genetic events for various cancers; yet, how m6A functions within the tumor …

Human in vitro fertilized embryos exhibit low developmental capabilities, and the
mechanisms that underlie embryonic arrest remain unclear. Here using a single-cell multi …

Keratinocyte cancers (KC) are the most prevalent malignancies in fair‐skinned populations,
posing a significant medical and economic burden to health systems. KC originate in the …

Background Neuroinflammation is one of the key factors leading to neuron death and
synapse dysfunction in Alzheimer's disease (AD). Amyloid-β (Aβ) is thought to have an …

Transplantation of stem cell–derived retinal pigment epithelial (RPE) cells is considered a
viable therapeutic option for age-related macular degeneration (AMD). Several landmark …

Gastrulation begins when the epiblast forms the primitive streak or becomes definitive
ectoderm. During this lineage bifurcation, the DNA dioxygenase TET1 has bipartite functions …

Background The triple negative breast cancer (TNBC) is the most malignant subtype of
breast cancer with high aggressiveness. Although paclitaxel-based chemotherapy scenario …