The roles and regulation of the KLF5 transcription factor in cancers

Y Luo, C Chen - Cancer science, 2021 - Wiley Online Library
Krüppel‐like factor 5 (KLF5) is a member of the KLF family. Recent studies have suggested
that KLF5 regulates the expression of a large number of new target genes and participates …

A time to heal: microRNA and circadian dynamics in cutaneous wound repair

S Fawcett, R Al Kassas, IM Dykes, ATL Hughes… - Clinical …, 2022 - portlandpress.com
Many biological systems have evolved circadian rhythms based on the daily cycles of
daylight and darkness on Earth. Such rhythms are synchronised or entrained to 24-h cycles …

Dioscin ameliorates methotrexate-induced liver and kidney damages via adjusting miRNA-145-5p-mediated oxidative stress

Y Li, M Gao, LH Yin, LN Xu, Y Qi, P Sun… - Free Radical Biology and …, 2021 - Elsevier
Dioscin, one natural product, has various pharmacological actions. However, its effects on
methotrexate (MTX)-induced hepatorenal damages still remain unknown. In the present …

Eukaryotic elongation factor 2 kinase promotes angiogenesis in hepatocellular carcinoma via PI3K/Akt and STAT3

Y Zhou, Y Li, S Xu, J Lu, Z Zhu, S Chen… - … journal of cancer, 2020 - Wiley Online Library
Hepatocellular carcinoma (HCC) is an aggressive malignancy with increasing mortality in
China. Angiogenesis is crucial for tumor formation, development and metastasis in HCC …

miR‐145‐5p affects the differentiation of gastric cancer by targeting KLF5 directly

T Zhou, S Chen, X Mao - Journal of cellular physiology, 2019 - Wiley Online Library
Krüppel‐like factor 5 (KLF5) takes part in the pathologic processes of many types of cancer;
however, its expression and roles in the biological behavior of gastric cancer remain …

Long non-coding RNA JPX correlates with poor prognosis and tumor progression in non-small-cell lung cancer by interacting with miR-145-5p and CCND2

M Jin, J Ren, M Luo, Z You, Y Fang, Y Han, G Li… - …, 2020 - academic.oup.com
Emerging studies have shown that the aberrant expression and function of long non-coding
RNAs (lncRNAs) are involved in carcinogenesis and the development of various cancers …

RNA sequencing-based identification of the regulatory mechanism of microRNAs, transcription factors, and corresponding target genes involved in vascular dementia

K Zhao, L Zeng, Z Cai, M Liu, T Sun, Z Li… - Frontiers in …, 2022 - frontiersin.org
Vascular dementia (VaD) is the second most common form of dementia with uncertain
mechanisms and no effective treatments. microRNAs (miRNAs) and transcription factors …

SPATS2, negatively regulated by miR-145-5p, promotes hepatocellular carcinoma progression through regulating cell cycle

G Dong, S Zhang, S Shen, L Sun, X Wang… - Cell Death & …, 2020 - nature.com
Spermatogenesis associated serine rich 2 (SPATS2) has been reported to contribute to the
tumorigenesis of multiple malignancies. The molecular function of SPATS2 in hepatocellular …

CircANKRD11 knockdown protects HPMECs from cigarette smoke extract-induced injury by regulating miR-145-5p/BRD4 axis

Z Wang, Y Zuo, Z Gao - International journal of chronic obstructive …, 2021 - Taylor & Francis
Background Chronic obstructive pulmonary disease (COPD) is a major cause of death
because of its high incidence and mortality, which is chiefly resulted from cigarette smoke …

P-MSC-derived extracellular vesicles facilitate diabetic wound healing via miR-145-5p/CDKN1A-mediated functional improvements of high glucose-induced …

J Su, Q Wei, K Ma, Y Wang, W Hu, H Meng, Q Li… - Burns & …, 2023 - academic.oup.com
Background Persistent hyperglycaemia in diabetes causes functional abnormalities of
human dermal fibroblasts (HDFs), partially leading to delayed skin wound healing …