Endothelial dysfunction in COVID-19: a position paper of the ESC Working Group for Atherosclerosis and Vascular Biology, and the ESC Council of Basic …
The COVID-19 pandemic is an unprecedented healthcare emergency causing mortality and
illness across the world. Although primarily affecting the lungs, the SARS-CoV-2 virus also …
illness across the world. Although primarily affecting the lungs, the SARS-CoV-2 virus also …
[HTML][HTML] Ischemic heart disease pathophysiology paradigms overview: from plaque activation to microvascular dysfunction
P Severino, A D'Amato, M Pucci, F Infusino… - International journal of …, 2020 - mdpi.com
Ischemic heart disease still represents a large burden on individuals and health care
resources worldwide. By conventions, it is equated with atherosclerotic plaque due to flow …
resources worldwide. By conventions, it is equated with atherosclerotic plaque due to flow …
[HTML][HTML] In-hospital use of statins is associated with a reduced risk of mortality among individuals with COVID-19
Statins are lipid-lowering therapeutics with favorable anti-inflammatory profiles and have
been proposed as an adjunct therapy for COVID-19. However, statins may increase the risk …
been proposed as an adjunct therapy for COVID-19. However, statins may increase the risk …
Direct activation of endothelial cells by SARS-CoV-2 nucleocapsid protein is blocked by Simvastatin
Emerging evidence suggests that endothelial activation plays a central role in the
pathogenesis of acute respiratory distress syndrome (ARDS) and multiorgan failure in …
pathogenesis of acute respiratory distress syndrome (ARDS) and multiorgan failure in …
Effect of statin therapy on SARS-CoV-2 infection-related mortality in hospitalized patients
Aim Assessing the effect of statin therapy (ST) at hospital admission for COVID-19 on in-
hospital mortality. Methods and results Retrospective observational study. Patients taking …
hospital mortality. Methods and results Retrospective observational study. Patients taking …
A comprehensive guide to the pharmacologic regulation of angiotensin converting enzyme 2 (ACE2), the SARS-CoV-2 entry receptor
The recent emergence of coronavirus disease-2019 (COVID-19) as a global pandemic has
prompted scientists to address an urgent need for defining mechanisms of disease …
prompted scientists to address an urgent need for defining mechanisms of disease …
[HTML][HTML] Statin use in COVID-19 hospitalized patients and outcomes: a retrospective study
H Kouhpeikar, H Khosaravizade Tabasi… - Frontiers in …, 2022 - frontiersin.org
Background Coronavirus disease 2019 (COVID-19) might affect everyone, but people with
comorbidities such as hypertension and cardiovascular disease (CVD) may often have more …
comorbidities such as hypertension and cardiovascular disease (CVD) may often have more …
[HTML][HTML] Targeting the SphK-S1P-SIPR pathway as a potential therapeutic approach for COVID-19
EM McGowan, N Haddadi, NT Nassif, Y Lin - International Journal of …, 2020 - mdpi.com
The world is currently experiencing the worst health pandemic since the Spanish flu in 1918—
the COVID-19 pandemic—caused by the coronavirus severe acute respiratory syndrome …
the COVID-19 pandemic—caused by the coronavirus severe acute respiratory syndrome …
Statin and mortality in COVID-19: a systematic review and meta-analysis of pooled adjusted effect estimates from propensity-matched cohorts
Purpose Statin potentially improved outcome in patients with COVID-19. Patients who
receive statin generally have a higher proportion of comorbidities than those who did not …
receive statin generally have a higher proportion of comorbidities than those who did not …
[HTML][HTML] Metabolic reprogramming in COVID-19
T Shen, T Wang - International journal of molecular sciences, 2021 - mdpi.com
Plenty of research has revealed virus induced alternations in metabolic pathways, which is
known as metabolic reprogramming. Studies focusing on COVID-19 have uncovered …
known as metabolic reprogramming. Studies focusing on COVID-19 have uncovered …