Advances in shotgun proteomics and the analysis of membrane proteomes

JM Gilmore, MP Washburn - Journal of proteomics, 2010 - Elsevier
The emergence of shotgun proteomics has facilitated the numerous biological discoveries
made by proteomic studies. However, comprehensive proteomic analysis remains …

Tumor suppressor miR-128-3p inhibits metastasis and epithelial–mesenchymal transition by targeting ZEB1 in esophageal squamous-cell cancer

L Zhao, R Li, S Xu, Y Li, P Zhao, W Dong… - Acta biochimica et …, 2018 - academic.oup.com
MicroRNAs (miRNAs) are some short RNAs that regulate multiple biological functions at
post-transcriptional levels, such as tumorigenic processes, inflammatory lesions and cell …

Tiny giants of gene regulation: experimental strategies for microRNA functional studies

BR Steinkraus, M Toegel… - Wiley Interdisciplinary …, 2016 - Wiley Online Library
The discovery over two decades ago of short regulatory microRNAs (miRNAs) has led to the
inception of a vast biomedical research field dedicated to understanding these powerful …

[HTML][HTML] A role for de novo purine metabolic enzyme PAICS in bladder cancer progression

BVSK Chakravarthi, MDCR Pena, S Agarwal… - Neoplasia, 2018 - Elsevier
Genomic and transcriptome sequencing of bladder cancer (BLCA) has identified multiple
molecular alterations during cancer progression. Many of these identified genetic and …

[HTML][HTML] miR-128-3p suppresses hepatocellular carcinoma proliferation by regulating PIK3R1 and is correlated with the prognosis of HCC patients

CY Huang, XP Huang, JY Zhu, ZG Chen… - Oncology …, 2015 - spandidos-publications.com
Abstract microRNAs (miRNAs) are known to be involved in the pathogenesis of
hepatocellular carcinoma (HCC). miR-128-3p was recently reported to be deregulated in …

Opposing gradients of microRNA expression temporally pattern layer formation in the developing neocortex

P Shu, C Wu, X Ruan, W Liu, L Hou, H Fu, M Wang… - Developmental Cell, 2019 - cell.com
The precisely timed generation of different neuronal types is a hallmark of development from
invertebrates to vertebrates. In the developing mammalian neocortex, neural stem cells …

Database-augmented mass spectrometry analysis of exosomes identifies claudin 3 as a putative prostate cancer biomarker

TS Worst, J Von Hardenberg, JC Gross, P Erben… - Molecular & Cellular …, 2017 - ASBMB
In prostate cancer and other malignancies sensitive and robust biomarkers are lacking or
have relevant limitations. Prostate specific antigen (PSA), the only biomarker widely used in …

Proteomic profiling of androgen-independent prostate cancer cell lines reveals a role for protein S during the development of high grade and castration-resistant …

P Saraon, N Musrap, D Cretu, GS Karagiannis… - Journal of Biological …, 2012 - ASBMB
Androgen deprivation constitutes the principal therapy for advanced and metastatic prostate
cancers. However, this therapeutic intervention usually results in the transition to a more …

MicroRNA-128 downregulates Bax and induces apoptosis in human embryonic kidney cells

YK Adlakha, N Saini - Cellular and Molecular Life Sciences, 2011 - Springer
Abstract MicroRNAs (miRNAs) are short~ 21-nt non-coding RNA molecules that have been
shown to regulate a number of biological processes. Previous reports have shown that …

The role of proteomics in prostate cancer research: biomarker discovery and validation

E Pin, C Fredolini, EF Petricoin III - Clinical biochemistry, 2013 - Elsevier
PURPOSE: Prostate Cancer (PCa) represents the second most frequent type of tumor in
men worldwide. Incidence increases with patient age and represents the most important risk …