Oxidative stress in intervertebral disc degeneration: molecular mechanisms, pathogenesis and treatment

Y Wang, H Cheng, T Wang, K Zhang, Y Zhang… - Cell …, 2023 - Wiley Online Library
Low back pain (LBP) is a leading cause of labour loss and disability worldwide, and it also
imposes a severe economic burden on patients and society. Among symptomatic LBP …

[HTML][HTML] Present and future perspective on PLK1 inhibition in cancer treatment

M Chiappa, S Petrella, G Damia, M Broggini… - Frontiers in …, 2022 - frontiersin.org
Polo-like kinase 1 (PLK1) is the principle member of the well conserved serine/threonine
kinase family. PLK1 has a key role in the progression of mitosis and recent evidence …

Exploring the role of lncrna neat1 knockdown in regulating apoptosis across multiple cancer types: A review

MS Hussain, G Gupta, M Afzal, SM Alqahtani… - … -Research and Practice, 2023 - Elsevier
Long non-coding RNAs (lncRNAs) have emerged as pivotal regulators of gene expression,
contributing significantly to a diverse range of cellular processes, including apoptosis. One …

Metal nanoparticles in cancer: from synthesis and metabolism to cellular interactions

HS Tuli, R Joshi, G Kaur, VK Garg, K Sak… - Journal of Nanostructure …, 2023 - Springer
Nanotechnology has encouraged new and amended materials (metal nanoparticles) for
therapeutic applications with specific prominence in healthcare. Metal nanoparticles (NPs) …

Organelle‐specific mechanisms in crosstalk between apoptosis and ferroptosis

P Wu, X Zhang, D Duan, L Zhao - Oxidative Medicine and …, 2023 - Wiley Online Library
Apoptosis has been extensively studied, whereas ferroptosis is a newly discovered form of
regulated cell death that involves iron‐dependent accumulations of lipid hydroperoxides …

Isolation and characterization of N‐(2‐Hydroxyethyl)hexadecanamide from Colletotrichum gloeosporioides with apoptosis‐inducing potential in breast cancer cells

N Rai, P Gupta, A Verma, SK Singh, V Gautam - BioFactors, 2023 - Wiley Online Library
Endophytic fungi are a well‐established reservoir of bioactive compounds that are
pharmaceutically valuable and therefore, contribute significantly to the biomedical field. The …

[HTML][HTML] Anti-inflammatory and anticancer properties of birch bark-derived betulin: Recent developments

HS Tuli, K Sak, DS Gupta, G Kaur, D Aggarwal… - Plants, 2021 - mdpi.com
Birch tree bark-derived betulin has attracted scientific interest already for several centuries,
being one of the first natural products identified from plants. However, the cellular events …

[HTML][HTML] Ferroptosis: a new hunter of hepatocellular carcinoma

Y Jiang, Y Yu, Z Pan, C Glandorff, M Sun - Cell Death Discovery, 2024 - nature.com
Ferroptosis is an iron ion-dependent, regulatory cell death modality driven by intracellular
lipid peroxidation that plays a key role in the development of HCC. Studies have shown that …

Natural products targeting signaling pathways associated with regulated cell death in gastric cancer: Recent advances and perspectives

Q Hu, Z Li, Y Li, X Deng, Y Chen, X Ma… - Phytotherapy …, 2023 - Wiley Online Library
Gastric cancer (GC) is one of the most serious gastrointestinal malignancies with high
morbidity and mortality. The complexity of GC process lies in the multi‐phenotypic linkage …

Change to the transcriptomic profile, oxidative stress, apoptotic and immunity in the liver of small yellow croaker (Larimichthys polyactis) under hypoxic stress

J Wang, L Wang, Y Liu, C Du, C Hou, Q Xie, D Tang… - Aquaculture, 2023 - Elsevier
The small yellow croaker (Larimichthys polyactis) is one of the most highly cultured fish in
China, contributing considerably to the country's economy. However, conditions …