The availability of public genomic resources can greatly assist biodiversity assessment,
conservation, and restoration efforts by providing evidence for scientifically informed …

Deleterious mutations decrease reproductive fitness and are ubiquitous in genomes. Given
that many organisms face ongoing threats of extinction, there is interest in elucidating the …

Many organisms have sex chromosomes with large nonrecombining regions that have
expanded stepwise, generating “evolutionary strata” of differentiation. The reasons for this …

Abstract The International Union for Conservation of Nature (IUCN) Red List is an important
and widely used tool for conservation assessment. The IUCN uses information about a …

Species persistence can be influenced by the amount, type, and distribution of diversity
across the genome, suggesting a potential relationship between historical demography and …

Our ability to assess the threat posed by the genetic load to small and declining populations
has been greatly improved by advances in genome sequencing and computational …

Theory predicts that genetic erosion in small, isolated populations of endangered species
can be assessed using estimates of neutral genetic variation, yet this widely used approach …

Hybrid potato breeding will transform the crop from a clonally propagated tetraploid to a
seed-reproducing diploid. Historical accumulation of deleterious mutations in potato …

The ongoing degradation of natural systems and other environmental changes has put our
society at a crossroad with respect to our future relationship with our planet. While the …

When new mutations arise at functional sites they are more likely to impair than improve
fitness. If not removed by purifying selection, such deleterious mutations will generate a …