Non-coding RNAs in disease: from mechanisms to therapeutics

K Nemeth, R Bayraktar, M Ferracin… - Nature Reviews Genetics, 2024 - nature.com
Non-coding RNAs (ncRNAs) are a heterogeneous group of transcripts that, by definition, are
not translated into proteins. Since their discovery, ncRNAs have emerged as important …

The regulation of lncRNAs and miRNAs in SARS-CoV-2 infection

Y Lin, Q Sun, B Zhang, W Zhao, C Shen - Frontiers in Cell and …, 2023 - frontiersin.org
The coronavirus disease 2019 (COVID-19) was a global endemic that continues to cause a
large number of severe illnesses and fatalities. There is increasing evidence that non-coding …

A chromatin-regulated biphasic circuit coordinates IL-1β-mediated inflammation

ET Fok, SJ Moorlag, Y Negishi, LA Groh… - Nature …, 2024 - nature.com
Inflammation is characterized by a biphasic cycle consisting initially of a proinflammatory
phase that is subsequently resolved by anti-inflammatory processes. Interleukin-1β (IL-1β) is …

[PDF][PDF] Interactomics: Dozens of Viruses, Co-evolving With Humans, Including the Influenza A Virus, may Actively Distort Human Aging

J Teulière, C Bernard, H Bonnefous… - Molecular biology …, 2023 - academic.oup.com
Some viruses (eg, human immunodeficiency virus 1 and severe acute respiratory syndrome
coronavirus 2) have been experimentally proposed to accelerate features of human aging …

Epigenetic regulation of pulmonary inflammation

S Ahmad, XL Zhang, A Ahmad - Seminars in cell & developmental biology, 2024 - Elsevier
Pulmonary disease such as chronic obstructive pulmonary disease (COPD), asthma,
pulmonary fibrosis and pulmonary hypertension are the leading cause of deaths. More …

Long noncoding RNA# 61 exerts a broad anti-influenza a virus effect by its long arm rings

J Hu, L Zhang, X Zheng, G Wang, X Chen, Z Hu… - Antiviral Research, 2023 - Elsevier
Emerging evidence has demonstrated the critical role of long noncoding RNAs (lncRNAs) in
regulating gene expression. However, the functional significance and mechanisms …

Single-cell epitope-transcriptomics reveal lung stromal and immune cell response kinetics to nanoparticle-delivered RIG-I and TLR4 agonists

MC Keenum, P Chatterjee, A Atalis, B Pandey… - Biomaterials, 2023 - Elsevier
Lung-resident and circulatory lymphoid, myeloid, and stromal cells, expressing various
pattern recognition receptors (PRRs), detect pathogen-and danger-associated molecular …

Eight influenza virus cellular manipulations which can boost concurrent SARS-CoV-2 infections to severe outcomes

K Roe - Human Cell, 2023 - Springer
Viral pathogens in the lungs can cause severe outcomes, including acute lung injury and
acute respiratory distress syndrome. Dangerous respiratory pathogens include some …

LncRNA LINC02574 Inhibits Influenza A Virus Replication by Positively Regulating the Innate Immune Response

Y Zhang, X Chi, J Hu, S Wang, S Zhao, Y Mao… - International Journal of …, 2023 - mdpi.com
Studies have shown that long noncoding RNAs (lncRNAs) play crucial roles in regulating
virus infection, host immune response, and other biological processes. Although some …

Exploration of the Noncoding Genome for Human-Specific Therapeutic Targets—Recent Insights at Molecular and Cellular Level

W Poller, S Sahoo, R Hajjar, U Landmesser… - Cells, 2023 - mdpi.com
While it is well known that 98–99% of the human genome does not encode proteins, but are
nevertheless transcriptionally active and give rise to a broad spectrum of noncoding RNAs …