GPX4 in cell death, autophagy, and disease

Y Xie, R Kang, DJ Klionsky, D Tang - Autophagy, 2023 - Taylor & Francis
ABSTRACT Selenoprotein GPX4 (glutathione peroxidase 4), originally known as PHGPX
(phospholipid hydroperoxide glutathione peroxidase), is the main oxidoreductase in the use …

Selenium in bodily homeostasis: hypothalamus, hormones, and highways of communication

P Toh, JL Nicholson, AM Vetter, MJ Berry… - International journal of …, 2022 - mdpi.com
The ability of the body to maintain homeostasis requires constant communication between
the brain and peripheral tissues. Different organs produce signals, often in the form of …

Selenoprotein‐Regulated Hydrogel for Ultrasound‐Controlled Microenvironment Remodeling to Promote Bone Defect Repair

R Xu, Y You, W Zheng, L Ma, Y Chang… - Advanced Functional …, 2024 - Wiley Online Library
Abnormal levels of reactive oxygen species (ROS) and the hypoxic microenvironment within
bone defects are important factors that impede bone repair processes. Herein, an innovative …

Association of COVID-19 mortality with serum selenium, zinc and copper: Six observational studies across Europe

K Demircan, TS Chillon, T Bracken, I Bulgarelli… - Frontiers in …, 2022 - frontiersin.org
Introduction Certain trace elements are essential for life and affect immune system function,
and their intake varies by region and population. Alterations in serum Se, Zn and Cu have …

Metal-coding assisted serological multi-omics profiling deciphers the role of selenium in COVID-19 immunity

Y Zhou, S Yuan, F Xiao, H Li, Z Ye, T Cheng, C Luo… - Chemical …, 2023 - pubs.rsc.org
Uncovering how host metal (loid) s mediate the immune response against invading
pathogens is critical for better understanding the pathogenesis mechanism of infectious …

Selenium intake and multiple health-related outcomes: an umbrella review of meta-analyses

P Wang, B Chen, Y Huang, J Li, D Cao, Z Chen… - Frontiers in …, 2023 - frontiersin.org
Selenium is an essential trace metalloid element that is associated with fundamental
importance to human health. Our umbrella review aimed to evaluate the quality of evidence …

Overview of antiviral drug therapy for COVID-19: where do we stand?

R Esposito, D Mirra, L Sportiello, G Spaziano… - Biomedicines, 2022 - mdpi.com
The vaccine weapon has resulted in being essential in fighting the COVID-19 outbreak, but it
is not fully preventing infection due to an alarming spreading of several identified variants of …

SARS-CoV-2 Main protease targets host selenoproteins and glutathione biosynthesis for knockdown via proteolysis, potentially disrupting the thioredoxin and …

IA Gallardo, DA Todd, ST Lima, JR Chekan, NH Chiu… - Antioxidants, 2023 - mdpi.com
Associations between dietary selenium status and the clinical outcome of many viral
infections, including SARS-CoV-2, are well established. Multiple independent studies have …

Selenium status and its determinants in very old adults: insights from the Newcastle 85+ Study

G Perri, JC Mathers, C Martin-Ruiz, C Parker… - British Journal of …, 2024 - cambridge.org
There is a dearth of data on Se status in very old adults. The aims of this study were to
assess Se status and its determinants in 85-year-olds living in the Northeast of England by …

Txnrd3 knockout enhancement of lung injury induced by Ni exposure via the VEGF-VEGFR-2 axis and alleviation of this effect by melatonin

P Liu, Y Sun, S Qiao, W Ma, L Xu, Y Liu, X Gai… - Food and Chemical …, 2023 - Elsevier
Ni exposure leads to respiratory diseases in mice. Txnrd3 has been shown to have a
protective effect on the body, but there is a paucity of empirical research focusing specifically …