Understanding COVID-19-associated coagulopathy

EM Conway, N Mackman, RQ Warren… - Nature Reviews …, 2022 - nature.com
Abstract COVID-19-associated coagulopathy (CAC) is a life-threatening complication of
SARS-CoV-2 infection. However, the underlying cellular and molecular mechanisms driving …

Current and novel biomarkers of thrombotic risk in COVID-19: a consensus statement from the international COVID-19 thrombosis biomarkers colloquium

DA Gorog, RF Storey, PA Gurbel, US Tantry… - Nature Reviews …, 2022 - nature.com
Abstract Coronavirus disease 2019 (COVID-19) predisposes patients to thrombotic and
thromboembolic events, owing to excessive inflammation, endothelial cell activation and …

Vasculopathy in COVID-19

R Flaumenhaft, K Enjyoji… - Blood, The Journal of the …, 2022 - ashpublications.org
COVID-19 is a primary respiratory illness that is frequently complicated by systemic
involvement of the vasculature. Vascular involvement leads to an array of complications …

Effect of P2Y12 inhibitors on survival free of organ support among non–critically ill hospitalized patients with COVID-19: a randomized clinical trial

JS Berger, LZ Kornblith, MN Gong, HR Reynolds… - Jama, 2022 - jamanetwork.com
Importance Platelets represent a potential therapeutic target for improved clinical outcomes
in patients with COVID-19. Objective To evaluate the benefits and risks of adding a P2Y12 …

Damage to endothelial barriers and its contribution to long COVID

X Wu, M Xiang, H Jing, C Wang, VA Novakovic, J Shi - Angiogenesis, 2024 - Springer
The world continues to contend with COVID-19, fueled by the emergence of viral variants. At
the same time, a subset of convalescent individuals continues to experience persistent and …

A central role for amyloid fibrin microclots in long COVID/PASC: origins and therapeutic implications

DB Kell, GJ Laubscher, E Pretorius - Biochemical Journal, 2022 - portlandpress.com
Post-acute sequelae of COVID (PASC), usually referred to as 'Long COVID'(a phenotype of
COVID-19), is a relatively frequent consequence of SARS-CoV-2 infection, in which …

COVID-19 and the vasculature: current aspects and long-term consequences

B Martinez-Salazar, M Holwerda, C Stuedle… - Frontiers in cell and …, 2022 - frontiersin.org
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) was first identified in
December 2019 as a novel respiratory pathogen and is the causative agent of Corona Virus …

Platelets and SARS-CoV-2 during COVID-19: immunity, thrombosis, and beyond

A Sciaudone, H Corkrey, F Humphries… - Circulation …, 2023 - Am Heart Assoc
COVID-19 is characterized by dysregulated thrombosis and coagulation that can increase
mortality in patients. Platelets are fast responders to pathogen presence, alerting the …

S100A8/A9 drives the formation of procoagulant platelets through GPIbα

M Colicchia, WC Schrottmaier… - Blood, The Journal …, 2022 - ashpublications.org
Abstract S100A8/A9, also known as “calprotectin” or “MRP8/14,” is an alarmin primarily
secreted by activated myeloid cells with antimicrobial, proinflammatory, and prothrombotic …

Endotheliopathy in acute COVID-19 and long COVID

AG Vassiliou, CS Vrettou, C Keskinidou… - International Journal of …, 2023 - mdpi.com
The pulmonary endothelium is a highly regulated organ that performs a wide range of
functions under physiological and pathological conditions. Since endothelial dysfunction …