Could SARS-CoV-2 spike protein be responsible for long-COVID syndrome?

TC Theoharides - Molecular Neurobiology, 2022 - Springer
SARS-CoV-2 infects cells via its spike protein binding to its surface receptor on target cells
and results in acute symptoms involving especially the lungs known as COVID-19. However …

Role of SARS-CoV-2 spike-protein-induced activation of microglia and mast cells in the pathogenesis of neuro-COVID

TC Theoharides, D Kempuraj - Cells, 2023 - mdpi.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus
disease 2019 (COVID-19). About 45% of COVID-19 patients experience several symptoms a …

Neuroinflammation and Its Impact on the Pathogenesis of COVID-19

MM Almutairi, F Sivandzade, TH Albekairi… - Frontiers in …, 2021 - frontiersin.org
Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2). The clinical manifestations of COVID-19 …

Can SARS-CoV-2 infection lead to neurodegeneration and Parkinson's disease?

L Krey, MK Huber, GU Höglinger, F Wegner - Brain Sciences, 2021 - mdpi.com
The SARS-CoV-2 pandemic has affected the daily life of the worldwide population since
2020. Links between the newly discovered viral infection and the pathogenesis of …

Recombinant SARS-CoV-2 Spike Protein and its Receptor Binding Domain stimulate release of different pro-inflammatory mediators via activation of distinct receptors …

I Tsilioni, TC Theoharides - Molecular Neurobiology, 2023 - Springer
SARS-CoV-2 infects cells via its spike (S) protein binding to its surface receptor angiotensin
converting enzyme 2 (ACE2) on target cells and results in acute symptoms involving …

Endothelial cell biomarkers in critically ill COVID‐19 patients with encephalitis

V Altmayer, J Ziveri, C Frère, JE Salem… - Journal of …, 2022 - Wiley Online Library
COVID‐19 is associated with encephalitis in critically ill patients and endothelial dysfunction
seems to contribute to this life‐threatening complication. Our objective was to determine the …

Association between COVID‐19 and myasthenia gravis (MG): A genetic correlation and Mendelian randomization study

D Sun, L Tu, X Wang, Q Du, R Wang, Z Shi… - Brain and …, 2023 - Wiley Online Library
Background: Observational studies have suggested an association between coronavirus
disease 2019 (COVID‐19) and myasthenia gravis (MG). Here, we aimed to estimate the …

[HTML][HTML] Long COVID: neurological manifestations-an updated narrative review

JW Leonel Tavares-Júnior, GCV Ciurleo… - Dementia & …, 2024 - SciELO Brasil
Infection with the SARS-CoV-2 virus can lead to neurological symptoms in the acute phase
and in the Long COVID phase. These symptoms usually involve cognition, sleep, smell …

Parkinson's disease and SARS-CoV-2 infection: particularities of molecular and cellular mechanisms regarding pathogenesis and treatment

A Anghelescu, G Onose, C Popescu, M Băilă, SI Stoica… - Biomedicines, 2022 - mdpi.com
Accumulating data suggest that chronic neuroinflammation-mediated neurodegeneration is
a significant contributing factor for progressive neuronal and glial cell death in age-related …

[HTML][HTML] Microbiota, probiotics and respiratory infections: the three musketeers can tip off potential management of COVID-19

AA Khan, HO Singh, M Bilal… - American Journal of …, 2021 - ncbi.nlm.nih.gov
Rapid infectivity of SARS-CoV2 with recent viral variants is posing a challenge in the
development of robust therapeutic strategies. On the other hand, microbiota is debated for its …