[PDF][PDF] Human immunodeficiency virus controllers: mechanisms of durable virus control in the absence of antiretroviral therapy
Chronic viral infections can appear in two very different forms: those that are typically
immunologically contained after acute symptomatic infection, such as Epstein-Barr virus …
immunologically contained after acute symptomatic infection, such as Epstein-Barr virus …
A HapMap harvest of insights into the genetics of common disease
TA Manolio, LD Brooks… - The Journal of clinical …, 2008 - Am Soc Clin Investig
The International HapMap Project was designed to create a genome-wide database of
patterns of human genetic variation, with the expectation that these patterns would be useful …
patterns of human genetic variation, with the expectation that these patterns would be useful …
Genomewide association analysis of coronary artery disease
Background Modern genotyping platforms permit a systematic search for inherited
components of complex diseases. We performed a joint analysis of two genomewide …
components of complex diseases. We performed a joint analysis of two genomewide …
How to interpret a genome-wide association study
TA Pearson, TA Manolio - Jama, 2008 - jamanetwork.com
Genome-wide association (GWA) studies use high-throughput genotyping technologies to
assay hundreds of thousands of single-nucleotide polymorphisms (SNPs) and relate them to …
assay hundreds of thousands of single-nucleotide polymorphisms (SNPs) and relate them to …
[HTML][HTML] The continuum of translation research in genomic medicine: how can we accelerate the appropriate integration of human genome discoveries into health care …
Advances in genomics have led to mounting expectations in regard to their impact on health
care and disease prevention. In light of this fact, a comprehensive research agenda is …
care and disease prevention. In light of this fact, a comprehensive research agenda is …
Discovering susceptibility genes for asthma and allergy
D Vercelli - Nature reviews immunology, 2008 - nature.com
Asthma and asthma-related traits are complex diseases with strong genetic and
environmental components. Rapid progress in asthma genetics has led to the identification …
environmental components. Rapid progress in asthma genetics has led to the identification …
Genome Wide Association (GWA) Study for Early Onset Extreme Obesity Supports the Role of Fat Mass and Obesity Associated Gene (FTO) Variants
Background Obesity is a major health problem. Although heritability is substantial, genetic
mechanisms predisposing to obesity are not very well understood. We have performed a …
mechanisms predisposing to obesity are not very well understood. We have performed a …
[HTML][HTML] Genetic and nongenetic risk factors for childhood cancer
LG Spector, N Pankratz, EL Marcotte - Pediatric Clinics of North …, 2015 - ncbi.nlm.nih.gov
The causes of childhood cancer have been systematically studied for several decades, but
apart from high-dose radiation and prior chemotherapy there are few or no strong external …
apart from high-dose radiation and prior chemotherapy there are few or no strong external …
From genetic privacy to open consent
JE Lunshof, R Chadwick, DB Vorhaus… - Nature Reviews …, 2008 - nature.com
Recent advances in high-throughput genomic technologies are showing concrete results in
the form of an increasing number of genome-wide association studies and in the publication …
the form of an increasing number of genome-wide association studies and in the publication …
Genetics of nonsyndromic orofacial clefts
F Rahimov, A Jugessur… - The Cleft palate …, 2012 - journals.sagepub.com
With an average worldwide prevalence of approximately 1.2/1000 live births, orofacial clefts
are the most common craniofacial birth defects in humans. Like other complex disorders …
are the most common craniofacial birth defects in humans. Like other complex disorders …