Background This study aimed to investigate the neuroanatomical subtypes among early-
onset schizophrenia (EOS) patients by exploring the association between structural …

Protein-coding differences between species often fail to explain phenotypic diversity,
suggesting the involvement of genomic elements that regulate gene expression such as …

Psychiatric disorders such as major depressive disorder (MDD), bipolar disorder (BD), and
schizophrenia (SCZ) are characterized by altered cognition and mood, brain functions that …

Susceptibility to schizophrenia is mediated by genetic and environmental risk factors.
Maternal immune activation by infections during pregnancy is hypothesized to be a key …

Background Schizophrenia is a complex and heterogeneous disorder involving multiple
regions and types of cells in the brain. Despite rapid progress made by genome-wide …

Psychiatric disorders and related traits have a demonstrated genetic component, with
heritability estimated by twin studies generally between 80% and 40%. Their pathogenesis …

Given most tissues are consist of abundant and diverse (sub-) cell types, an important yet
unaddressed problem in bulk RNA-seq analysis is to identify at which (sub-) cell type (s) the …

Single cell approaches have increased our knowledge about the cell type composition of the
non-human primate (NHP), but a detailed characterization of area-specific regulatory …

Cognitive deficits are a hallmark of schizophrenia, for which no convincing pharmacological
treatment option is currently available. Here, we tested spironolactone as a repurposed …

Susceptibility to schizophrenia is mediated by genetic and environmental risk factors.
Infection driven maternal immune activation (MIA) during pregnancy is a key environmental …