Pro-resolving lipid mediators are leads for resolution physiology

CN Serhan - Nature, 2014 - nature.com
Advances in our understanding of the mechanisms that bring about the resolution of acute
inflammation have uncovered a new genus of pro-resolving lipid mediators that include the …

The resolution code of acute inflammation: Novel pro-resolving lipid mediators in resolution

CN Serhan, N Chiang, J Dalli - Seminars in immunology, 2015 - Elsevier
Studies into the mechanisms in resolution of self-limited inflammation and acute reperfusion
injury have uncovered a new genus of pro-resolving lipid mediators coined specialized pro …

Marine omega‐3 (n‐3) phospholipids: A comprehensive review of their properties, sources, bioavailability, and relation to brain health

MK Ahmmed, F Ahmmed, H Tian… - … reviews in food …, 2020 - Wiley Online Library
For several decades, there has been considerable interest in marine‐derived long chain n‐3
fatty acids (n‐3 LCPUFAs) due to their outstanding health benefits. n‐3 LCPUFAs can be …

[HTML][HTML] Advances in our understanding of oxylipins derived from dietary PUFAs

M Gabbs, S Leng, JG Devassy, M Monirujjaman… - Advances in …, 2015 - Elsevier
Oxylipins formed from polyunsaturated fatty acids (PUFAs) are the main mediators of PUFA
effects in the body. They are formed via cyclooxygenase, lipoxygenase, and cytochrome …

Omega-3 fatty acid-derived mediators that control inflammation and tissue homeostasis

T Ishihara, M Yoshida, M Arita - International immunology, 2019 - academic.oup.com
Omega-3 polyunsaturated fatty acids (PUFAs), including eicosapentaenoic acid,
docosapentaenoic acid and docosahexaenoic acid, display a wide range of beneficial …

Resolution phase lipid mediators of inflammation: agonists of resolution

CN Serhan, N Chiang - Current opinion in pharmacology, 2013 - Elsevier
Highlights•The n-3 specialized pro-resolving mediators (SPM) evoke stereoselective
actions.•SPM control excessive PMN and stimulate macrophage clearance, vital for …

[HTML][HTML] Role of omega-3 fatty acids and their metabolites in asthma and allergic diseases

J Miyata, M Arita - Allergology International, 2015 - Elsevier
Omega-3 fatty acids, docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), are
found naturally in fish oil and are commonly thought to be anti-inflammatory nutrients, with …

Resolution of acute inflammation in the lung

BD Levy, CN Serhan - Annual review of physiology, 2014 - annualreviews.org
Acute inflammation in the lung is essential to health. So too is its resolution. In response to
invading microbes, noxious stimuli, or tissue injury, an acute inflammatory response is …

E-series resolvin metabolome, biosynthesis and critical role of stereochemistry of specialized pro-resolving mediators (SPMs) in inflammation-resolution: Preparing …

CN Serhan, S Libreros, R Nshimiyimana - Seminars in immunology, 2022 - Elsevier
The COVID-19 pandemic has raised international awareness of the importance of rigorous
scientific evidence and the havoc caused by uncontrolled excessive inflammation. Here we …

Resolvins and cysteinyl-containing pro-resolving mediators activate resolution of infectious inflammation and tissue regeneration

CN Serhan, N Chiang - Prostaglandins & other lipid mediators, 2023 - Elsevier
This review is a synopsis of the main points from the opening presentation by the authors in
the Resolution of Inflammation session at the 8th European Workshop on Lipid Mediators …