Polymorphism in the apolipoprotein E (APOE) gene is a major genetic risk determinant of
late-onset Alzheimer disease (AD), with the APOE* ε 4 allele conferring an increased risk …

Alzheimer's disease (AD) is a devastating neurodegenerative disorder characterized by
extracellular amyloid β (Aβ) and intraneuronal tau protein aggregations. One risk factor for …

Alzheimer's disease (AD) is an age‐associated neurodegenerative disorder with
multifactorial etiology, intersecting genetic and environmental risk factors, and a lack of …

While the central nervous system compromises 2% of our body weight, it harbors up to 25%
of the body's cholesterol. Cholesterol levels in the brain are tightly regulated for …

Apolipoprotein E (ApoE) is of great interest due to its role as a cholesterol/lipid transporter in
the central nervous system (CNS) and as the most influential genetic risk factor for Alzheimer …

Investigations of apolipoprotein E (APOE) gene, the major genetic risk modifier for
Alzheimer's disease (AD), have yielded significant insights into the pathogenic mechanism …

Background The growing body of evidence indicating the heterogeneity of Alzheimer's
disease (AD), coupled with disappointing clinical studies directed at a fit-for-all therapy …

Dysregulation of lipid metabolism has emerged as a central component of many
neurodegenerative diseases. Variants of the lipid transport protein, apolipoprotein E …

Tau protein plays a critical role in the assembly, stabilization, and modulation of
microtubules, which are important for the normal function of neurons and the brain. In …

Apolipoprotein E (APOE) is the major cholesterol carrier in the brain, affecting various
normal cellular processes including neuronal growth, repair and remodeling of membranes …