The activation of fibroblasts is required for physiological tissue remodelling such as wound
healing. However, when the regulatory mechanisms are disrupted and fibroblasts remain …

Methylation of cytosine residues in DNA, the best studied epigenetic modification, is
associated with gene transcription and nuclear organization, and ultimately the function of a …

Autoimmune rheumatic diseases pose many problems that have, in general, already been
solved in the field of cancer. The heterogeneity of each disease, the clinical similarities and …

Subglottic stenosis (SGS) is a narrowing of the airway just below the vocal cords. This
narrowing typically consists of fibrotic scar tissue, which may be due to a variety of diseases …

Systemic sclerosis (SSc, scleroderma) is a complex multisystem disease characterized by
autoimmunity, vasculopathy, and most notably, fibrosis. Multiple lines of evidence …

Systemic sclerosis (SSc) is manifested by fibrosis, vasculopathy and immune dysregulation.
So far, a unifying hypothesis underpinning these pathological events remains unknown …

Systemic sclerosis (SSc) is a severe autoimmune disease that is characterized by vascular
abnormalities, immunological alterations and fibrosis of the skin and internal organs. The …

Scleroderma (SSc) is a complex disease that involves activation of the immune system,
vascular complications, and tissue fibrosis. The histone methyltransferase enhancer of zeste …

Systemic lupus erythematosus is a multi-system disease characterized by wide-spread DNA
methylation changes. To identify epigenetic susceptibility loci for lupus nephritis, genome …

With unknown etiology, scleroderma (SSc) is a multifaceted disease characterized by
immune activation, vascular complications, and excessive fibrosis in internal organs …