Genetics and genomics of psychiatric disease

DH Geschwind, J Flint - Science, 2015 - science.org
Large-scale genomic investigations have just begun to illuminate the molecular genetic
contributions to major psychiatric illnesses, ranging from small-effect-size common variants …

Sensory processing dysfunction in the personal experience and neuronal machinery of schizophrenia

DC Javitt, R Freedman - American Journal of Psychiatry, 2015 - Am Psychiatric Assoc
Sensory processing deficits, first investigated by Kraepelin and Bleuler as possible
pathophysiological mechanisms in schizophrenia, are now being recharacterized in the …

Neurocognitive growth charting in psychosis spectrum youths

RC Gur, ME Calkins, TD Satterthwaite… - JAMA …, 2014 - jamanetwork.com
Importance Psychosis-risk studies have examined help-seeking adolescents and young
adults. Population-based studies evaluating psychotic symptoms and neurocognitive …

Sensorimotor gating of the startle reflex: what we said 25 years ago, what has happened since then, and what comes next

NR Swerdlow, DL Braff… - Journal of …, 2016 - journals.sagepub.com
Our 1992 paper,'The neural substrates of sensorimotor gating of the startle reflex: a review of
recent findings and their implications', reviewed a series of (then) new and preliminary …

Bipolar and schizophrenia network for intermediate phenotypes: outcomes across the psychosis continuum

CA Tamminga, G Pearlson, M Keshavan… - Schizophrenia …, 2014 - academic.oup.com
Bipolar and schizophrenia network for intermediate phenotypes is a network of investigator-
driven laboratories focused on developing phenotypes, genotypes, and biomarkers for …

Recent advances in the genetics of schizophrenia

D Avramopoulos - Complex Psychiatry, 2018 - karger.com
The last decade brought tremendous progress in the field of schizophrenia genetics. As a
result of extensive collaborations and multiple technological advances, we now recognize …

[HTML][HTML] Genetic associations between voltage-gated calcium channels and psychiatric disorders

A Andrade, A Brennecke, S Mallat, J Brown… - International journal of …, 2019 - mdpi.com
Psychiatric disorders are mental, behavioral or emotional disorders. These conditions are
prevalent, one in four adults suffer from any type of psychiatric disorders world-wide. It has …

Genome-wide association of endophenotypes for schizophrenia from the Consortium on the Genetics of Schizophrenia (COGS) study

TA Greenwood, LC Lazzeroni, AX Maihofer… - JAMA …, 2019 - jamanetwork.com
Importance The Consortium on the Genetics of Schizophrenia (COGS) uses quantitative
neurophysiological and neurocognitive endophenotypes with demonstrated deficits in …

[HTML][HTML] Oxytocin in schizophrenia: pathophysiology and implications for future treatment

KK Goh, CH Chen, HY Lane - International journal of molecular sciences, 2021 - mdpi.com
Schizophrenia is a form of mental disorder that is behaviorally characterized by abnormal
behavior, such as social function deficits or other behaviors that are disconnected from …

Explaining additional genetic variation in complex traits

MR Robinson, NR Wray, PM Visscher - Trends in Genetics, 2014 - cell.com
Genome-wide association studies (GWAS) have provided valuable insights into the genetic
basis of complex traits, discovering> 6000 variants associated with> 500 quantitative traits …