The event of mutations in the surface antigen gene of hepatitis B virus (HBV) results in
undetectable hepatitis B surface antigen with positive/negative anti-hepatitis B core (anti …

Hepatitis B virus (HBV) reactivation occurs as a major complication of immunosuppressive
therapy among persons who have recovered from acute hepatitis and those who have …

Occult hepatitis B infection (OBI) is a status of undetectable serum hepatitis B surface
antigen (HBsAg) yet detectable serum and/or intrahepatic hepatitis B virus (HBV) DNA …

More than 95% of adult infected with HBV show acute self-limited infection and eventually
eliminate the virus. In contrast, about 90% of people exposed to HBV in early childhood …

Background: Gaps remain in the detection of nucleic acid test (NAT) yield and occult
hepatitis B virus (HBV) infection (OBI) by current HBV surface antigen (HBsAg) assays. The …

Serum samples identified as positive for total anti-HBc, but negative for both HBsAg and anti-
HBs, are referred to as anti-HBc alone. This serological response is compatible with acute …

Hepatitis B virus (HBV) infection is a global public health concern. HBV causes chronic
infection in patients and can lead to liver cirrhosis, hepatocellular carcinoma, and other …

Occult hepatitis B infection (OBI) is characterized by the detection of hepatitis B virus (HBV)
DNA in serum or liver but negativity for hepatitis B surface antigen. OBI, which is thought to …

Background Clinically, some patients whose HBsAg becomes negative owing to antiviral
therapy or spontaneously still show a low level of HBV DNA persistence in serum. T …

Abstract Purpose of Review It is crucial for clinicians to understand the need to screen for
hepatitis B core antigen (anti-HBc status), proper interpretation of HBV biomarkers, and that …