Pathophysiology, evaluation, and management of chronic watery diarrhea

M Camilleri, JH Sellin, KE Barrett - Gastroenterology, 2017 - Elsevier
Chronic watery diarrhea poses a diagnostic and therapeutic challenge and is often a
disabling condition for patients. Although acute diarrhea is likely to be caused by infection …

Simulating human gastrointestinal motility in dynamic in vitro models

Y Li, F Kong - Comprehensive Reviews in Food Science and …, 2022 - Wiley Online Library
The application of dynamic in vitro gastrointestinal (GI) models has grown in popularity to
understand the impact of food structure and composition on human health. Given that GI …

[HTML][HTML] Multi-strain probiotics (Hexbio) containing MCP BCMC strains improved constipation and gut motility in Parkinson's disease: A randomised controlled trial

A Ibrahim, RAR Ali, MRA Manaf, N Ahmad… - Plos one, 2020 - journals.plos.org
Objective We determined the effectiveness of a multi-strain probiotic (Hexbio®) containing
microbial cell preparation MCP® BCMC® on constipation symptoms and gut motility in PD …

[HTML][HTML] Temperature-triggered in situ forming lipid mesophase gel for local treatment of ulcerative colitis

M Carone, MR Spalinger, RA Gaultney… - Nature …, 2023 - nature.com
Ulcerative colitis is a chronic inflammatory bowel disease that strongly affects patient quality
of life. Side effects of current therapies necessitate new treatment strategies that maximise …

Physiology of the neonatal gastrointestinal system relevant to the disposition of orally administered medications

A Neal-Kluever, J Fisher, L Grylack… - Drug metabolism and …, 2019 - ASPET
A thorough knowledge of the newborn (age, birth to 1 month postpartum) infant's
gastrointestinal tract (GIT) is critical to the evaluation of the absorption, distribution …

[HTML][HTML] Depletion of muscularis macrophages ameliorates inflammation-driven dysmotility in murine colitis model

S Ferenczi, F Mogor, P Takacs, T Kovacs, VE Toth… - Scientific Reports, 2023 - nature.com
Previously, the presence of a blood-myenteric plexus barrier and its disruption was reported
in experimentally induced colitis via a macrophage-dependent process. The aim of this …

In vivo models to evaluate ingestible devices: Present status and current trends

K Stamatopoulos, C O'farrell, M Simmons… - Advanced Drug Delivery …, 2021 - Elsevier
Abstract Evaluation of orally ingestible devices is critical to optimize their performance early
in development. Using animals as a pre-clinical tool can provide useful information on …

Established and emerging methods for assessment of small and large intestinal motility

D Grønlund, JL Poulsen, TH Sandberg… - …, 2017 - Wiley Online Library
Background Gastrointestinal symptoms are common in the general population and may
originate from disturbances in gut motility. However, fundamental mechanistic …

Ambulatory assessment of colonic motility using the electromagnetic capsule tracking system

EB Mark, JL Poulsen, AM Haase… - …, 2019 - Wiley Online Library
Abstract Background The Motilis 3D‐Transit system tracks electromagnetic capsules as they
traverse the gastrointestinal tract. The method is minimally invasive and ambulatory …

[HTML][HTML] Distal colon motor dysfunction in mice with chronic kidney disease: putative role of uremic toxins

E Hoibian, N Florens, L Koppe, H Vidal, CO Soulage - Toxins, 2018 - mdpi.com
Although gastrointestinal complications are a common feature of patients with chronic
kidney disease (CKD), the impact of uremia on bowel motility remains poorly understood …