Simple Summary Breast cancer is one of the leading causes of death among women
worldwide. Breast cancer may be provoked due to several physical, chemical and …

The current approach to systemic therapy for metastatic cancer is aimed predominantly at
inducing apoptosis of cancer cells by blocking tumor-promoting signaling pathways or by …

Network pharmacology uses bioinformatics to broaden our understanding of drug actions
and thereby to advance drug discovery. Here we apply network pharmacology to generate …

BACKGROUND Given the complex pathogenesis of ulcerative colitis (UC), the conventional
therapeutic methods are not fully curative. As a sort of systematic complementary and …

Phosphatases can dephosphorylate phosphorylated kinases, leading to their inactivation,
and ferroptosis is a type of cell death. Therefore, our aim is to identify phosphatases …

Therapeutic cancer vaccines are novel immuno-therapeutics, aiming to improve clinical
outcomes with other immunotherapies. However, obstacles to their successful clinical …

Background: Due to its ability to provide quantitative and dynamic information on tumor
genesis and development by directly profiling protein expression, the proteomics has …

Introduction: Cervical cancer remains a significant global health burden, and Doxorubicin is
a crucial therapeutic agent against this disease. However, the precise molecular …

Quantitative systems pharmacology (QSP) modeling has become an increasingly popular
approach impacting our understanding of disease mechanisms and helping predict patients' …

The use of pharmacotherapy for improving healthcare in society is increasing. A vast
majority of patients have either received subtherapeutic treatment (which could result from …