The β-lactams are the most widely used antibacterial agents worldwide. These antibiotics, a
group that includes the penicillins and cephalosporins, are covalent inhibitors that target …

Resistance to β-lactam antibiotics is rapidly growing, substantially due to the spread of
serine-β-lactamases (SBLs) and metallo-β-lactamases (MBLs), which efficiently catalyse β …

Protein stability is an essential property for biological function. In contrast to the vast
knowledge on protein stability in vitro, little is known about the factors governing in-cell …

The sulfonamides (sulfas) are the oldest class of antibacterial drugs and inhibit the bacterial
dihydropteroate synthase (DHPS, encoded by folP), through chemical mimicry of its co …

Klebsiella pneumoniae as a main opportunistic pathogen is a common cause of health-care-
associated bacterial infections, which has shown high levels of drug resistance specifically …

The biofilm is a bacterial colony wrapped in an auto-produced polymer matrix of
polysaccharides, proteins, and DNA. Bacterial biofilms cause persistent infections because …

Abstract β-lactam antibiotics are widely used chemical compounds in medicine due to their
strong antibacterial activity. These drugs are produced by fungi (Penicillium …

Gram-negative bacterial resistance to antimicrobials has had an exponential increase at a
global level during the last decades and represent an everyday challenge, especially for the …

Abstract Metallo-β-lactamases (MBLs) are zinc-dependent hydrolases that inactivate
virtually all β-lactam antibiotics. The expression of MBLs by Gram-negative bacteria severely …

Catalytic semihydrogenation of internal alkynes using H2 is an attractive atom-economical
route to various alkenes, and its stereocontrol has received widespread attention, both in …