Iron is an essential trace element for the human body, and its deficiency or excess can
induce a variety of biological processes. Plenty of evidences have shown that iron …

Cancer cells undergo considerable metabolic changes to foster uncontrolled proliferation in
a hostile environment characterized by nutrient deprivation, poor vascularization and …

Papillary thyroid cancer (PTC) is a common endocrine system malignancy all over the world.
Aberrant expression of six transmembrane epithelial antigen of the prostate 2 (STEAP2) has …

Background The esophageal microbiome has been proposed to be involved in a range of
diseases including the esophageal adenocarcinoma cascade; however, little is currently …

Recent advances in sequencing technology allow genome-scale approaches to cancer
mutation discovery. Such data-intensive methods have been applied to cutaneous …

Prostate cancer is the most commonly diagnosed malignancy in men and the second
leading cause of cancer-related deaths in Western civilization. Although localized prostate …

Background: Among head and neck squamous cell carcinomas (HNSCCs), hypopharyngeal
squamous cell carcinoma (HPSCC) has the worst prognosis. Iron metabolism, which plays a …

Purpose: Ewing sarcoma is the second most common bone sarcoma in children, with 1 case
per 1.5 million in the United States. Although the survival rate of patients diagnosed with …

Lysophosphatidic acid (LPA) is a ubiquitously present signalling molecule involved in
diverse cellular processes such as cell migration, proliferation and differentiation. LPA acts …

Copper is vital for numerous cellular functions affecting all tissues and organ systems in the
body. The copper pump, ATP7A is critical for whole-body, cellular, and subcellular copper …