Osteoporosis is caused by the disruption in homeostasis between bone formation and bone
resorption. Conventional management of osteoporosis involves systematic drug …

Bone diseases including osteoarthritis, osteoporosis, and bone tumors are becoming severe
threats to public health. Bone-targeted biomaterials-based strategies could improve …

The effective regeneration of weight‐bearing bone defects and critical‐sized cartilage
defects remains a significant clinical challenge. Traditional treatments such as autologous …

Dendrimers are used for a variety of applications in medicine but, due to their host–guest
and entrapment characteristics, are particularly used for the delivery of genes and drugs …

Drug delivery for osteoarthritis (OA) treatment is a continuous challenge because of their
poor bioavailability and rapid clearance in joints. Intra-articular (IA) drug delivery is a …

Dendrimers have been comprehensively used for cargo delivery, nucleic acid delivery
(genes, miRNA/siRNAs), delivery of macromolecules, and other various biomedical …

This study aimed to improve the mechanical, drug loading/release and bioactive
characteristics of hydroxyapatite (HAP). The covalent functionalization of PAMAM dendrimer …

The mitochondrial permeability transition (mPT) directly affects mitochondrial function in
macrophages. Under inflammatory conditions, mitochondrial calcium ion (mitoCa2+) …

Purpose: In order to overcome the problem that conventional pharmacological treatments of
periodontitis cannot effectively synergizing antimicrobial and immunomodulation, inspired …

Polyamidoamines (PAMAMs) are a class of dendrimer with monodispersity and controlled
topology, which can deliver biologically active macromolecules (eg, genes and proteins) to …