The assembly of ribosomal subunits is a highly orchestrated process that involves a huge
cohort of accessory factors. Most eukaryotic ribosome biogenesis factors were first identified …

Ribosomes are highly conserved ribonucleoprotein nanomachines that translate information
in the genome to create the proteome in all cells. In yeast these complex particles contain …

DDX41 mutations are the most common germline alterations in adult myelodysplastic
syndromes (MDSs). The majority of affected individuals harbor germline monoallelic …

Significant recent advances in structural biology, particularly in the field of cryoelectron
microscopy, have dramatically expanded our ability to create structural models of proteins …

Ribosomal RNAs are produced as lengthy polycistronic precursors containing coding and
non-coding sequences, implying that extensive pre-rRNA processing is necessary for the …

The molecular weight (MW) of a protein can be predicted based on its amino acids (AA)
composition. However, in many cases a non-chemically modified protein shows an SDS …

Ribosome synthesis requires a multitude of cofactors, among them DExD/H-box RNA
helicases. Bacterial RNA helicases involved in ribosome assembly are not essential, while …

The small subunit (SSU) processome is a 2.2‐MDa ribonucleoprotein complex involved in
the processing, assembly, and maturation of the SSU of eukaryotic ribosomes. The identities …

At least 30% of human proteins are thought to contain intrinsically disordered regions, which
lack stable structural conformation. Despite lacking enzymatic functions and having few …

Abstract p53 protein turnover through the ubiquitination pathway is a vital mechanism in the
regulation of its transcriptional activity; however, little is known about p53 turnover through …