The cingulum bundle is a prominent white matter tract that interconnects frontal, parietal, and
medial temporal sites, while also linking subcortical nuclei to the cingulate gyrus. Despite its …

Recent decades have witnessed tremendous advances in the neuroscience of emotion,
learning and memory, and in animal models for understanding depression and anxiety. This …

Background The optimal target in the dorsolateral prefrontal cortex for treating depression
with repetitive transcranial magnetic stimulation (rTMS) remains unknown. Better efficacy …

The promise of machine learning has fueled the hope for developing diagnostic tools for
psychiatry. Initial studies showed high accuracy for the identification of major depressive …

Importance Currently, fewer than 40% of patients treated for major depressive disorder
achieve remission with initial treatment. Identification of a biological marker that might …

Treatment-resistant depression is a severely disabling disorder with no proven treatment
options once multiple medications, psychotherapy, and electroconvulsive therapy have …

BACKGROUND: Positron emission tomography (PET) studies of major depression have
revealed resting-state abnormalities in the prefrontal and cingulate cortices. Recently, fMRI …

Carriers of the short allele of a functional 5′ promoter polymorphism of the serotonin
transporter gene have increased anxiety-related temperamental traits, increased amygdala …

BACKGROUND: We investigated the use of deep brain stimulation (DBS) of the ventral
capsule/ventral striatum (VC/VS) for treatment refractory depression. METHODS: Fifteen …

The subcallosal cingulate gyrus (SCG), including Brodmann area 25 and parts of 24 and 32,
is the portion of the cingulum that lies ventral to the corpus callosum. It constitutes an …