Background The candidate malaria vaccine RTS, S/AS01E has entered phase 3 trials, but
data on long-term outcomes are limited. Methods For 4 years, we followed children who had …

Vaccines are one of the most effective interventions to improve public health, however, the
generation of highly effective vaccines for many diseases has remained difficult. Three …

Subunit vaccines are significantly more expensive to produce than traditional vaccines
because they are based primarily on recombinant proteins that must be purified from the …

Historically, vaccines have been designed to mimic the immunity induced by natural
exposure to the target pathogen, but this approach has not been effective for any parasitic …

Malaria transmission is in decline in some parts of Africa, partly due to the scaling up of
control measures. If the goal of elimination is to be achieved, additional control measures …

Plasmodium falciparum is an intracellular protozoan parasite that infects erythrocytes and
hepatocytes. The blood stage of its life cycle causes substantial morbidity and mortality …

In October 2021, the world's first malaria vaccine RTS, S was endorsed by WHO for broad
use in children, despite its low efficacy. This study examined polyclonal infections and the …

Erythrocyte invasion by Plasmodium falciparum merozoites is an essential step for parasite
survival and proliferation. Invasion is mediated by multiple ligands, which could be …

If ever there were a truism then it would be that a completely protective Plasmodium
falciparum malaria vaccine is desperately needed. Our institute has devoted all its efforts …

Event dependence, the phenomenon in which future risk depends on past disease history, is
not commonly accounted for in the statistical models used by malaria researchers. However …