Certain morphological, physiological and molecular characteristics are shared by all
neurons. However, despite these similarities, neurons constitute the most diverse cell …

Stem cell transplantation may repair the injured heart, but tissue regeneration is limited by
death of transplanted cells. Most cell death occurs in the first few days post-transplantation …

Understanding the molecular mechanisms that promote successful tissue regeneration is
critical for continued advancements in regenerative medicine. Vertebrate amphibian …

Transgenesis is an important tool for assessing gene function. In zebrafish, transgenesis has
suffered from three problems: the labor of building complex expression constructs using …

TGF-β signals from the membrane to the nucleus through serine/threonine kinase receptors
and their downstream effectors, termed SMAD proteins. The activated TGF-β receptor …

Notch proteins are ligand-activated transmembrane receptors involved in cell-fate selection
throughout development,,. No known enzymatic activity is contained within Notch and the …

The proliferation and differentiation of cells of many lineages are regulated by secreted
proteins known as cytokines. Cytokines exert their biological effect through binding to cell …

Mitogen‐activated protein (MAP) kinases bind tightly to many of their physiologically
relevant substrates. We have identified a new subfamily of murine serine/threonine kinases …

We report here development of a novel gene trap method in zebrafish using the Tol2
transposon system. First, we established a highly efficient transgenesis method in which a …

Abstract γ-secretase-like proteolysis at site 3 (S3), within the transmembrane domain,
releases the Notch intracellular domain (NICD) and activates CSL-mediated Notch …